IDEAS home Printed from https://ideas.repec.org/a/ibn/jasjnl/v8y2015i1p154.html
   My bibliography  Save this article

Tilmicosin Reduces PRRSV Loads in Pigs in vivo

Author

Listed:
  • Chao-Nan Lin
  • Yu-Jian Yang
  • Wei-Hao Lin
  • Hsien-Ching Wu
  • Zhixuan Xiong
  • Wouter Depondt
  • Alain Kanora
  • Min Cui
  • Danping Su
  • Dongsheng He
  • Ming-Tang Chiou

Abstract

Porcine respiratory and reproductive syndrome virus (PRRSV) is an important pathogen having a significant economic impact on the swine industry worldwide. Tilmicosin is a new semi-synthetic macrolide antibiotic developed from tylosin B. Tilmicosin can enter pulmonary alveolar macrophages (PAMs) and inhibit the replication of PRRSV in PAMs in vitro. This study was conducted to evaluate the impact of tilmicosin in controlling the replication of PRRSV in vivo. Forty and 635 weaned piglets were randomly chosen from PRRSV-contaminated farrow-to-finish herds in Taiwan and China, respectively. The piglets were equally divided into two groups and housed in the same pen but separated into individual spaces. Tilmicosin (Tilmovet® 20% premix, 400 mg/kg) was administered after weaning for 21 days (treated group). The untreated group of piglets did not receive tilmicosin. Blood samples were collected at 4, 6, 8, 10 and 12 weeks of age to detect of the PRRSV load. At 8 and 10 weeks of age, the tilmicosin-treated piglets had a significantly lower PRRSV load than the untreated piglets (P < 0.05) in Taiwan. At 6, 8, 10, and 12 weeks of age, the tilmicosin-treated piglets had a significantly lower PRRSV load than the untreated piglets (P < 0.05) in China. These data indicates that animals treated with tilmicosin exhibited not only reduced PRRSV loads but also improved average daily weight gain during the study period.

Suggested Citation

  • Chao-Nan Lin & Yu-Jian Yang & Wei-Hao Lin & Hsien-Ching Wu & Zhixuan Xiong & Wouter Depondt & Alain Kanora & Min Cui & Danping Su & Dongsheng He & Ming-Tang Chiou, 2015. "Tilmicosin Reduces PRRSV Loads in Pigs in vivo," Journal of Agricultural Science, Canadian Center of Science and Education, vol. 8(1), pages 154-154, December.
    • Handle: RePEc:ibn:jasjnl:v:8:y:2015:i:1:p:154
    as

    Download full text from publisher

    File URL: https://ccsenet.org/journal/index.php/jas/article/download/54549/29752
    Download Restriction: no
    File URL: https://ccsenet.org/journal/index.php/jas/article/view/54549
    Download Restriction: no
    ---><---

    More about this item

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:ibn:jasjnl:v:8:y:2015:i:1:p:154. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Canadian Center of Science and Education (email available below). General contact details of provider: https://edirc.repec.org/data/cepflch.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.