IDEAS home Printed from https://ideas.repec.org/a/ibn/jasjnl/v7y2015i8p131.html
   My bibliography  Save this article

DNA Sequence Characteristics and Phylogenetics of Putative Imprinted Genes on Bovine Chromosome 29

Author

Listed:
  • Oladeji Bamidele
  • O. Omitogun
  • I. Imumorin

Abstract

Cattle are important livestock species with huge genetic resource for food security, agriculture and livelihoods. Over 60% of its genes are homologous to all mammalian species which creates a molecular basis for conducting comparative genomic analysis. Genomic imprinting has been implicated in a variety of biological functions and so identification of new or verification of known imprinted genes in livestock species is of high agricultural and biomedical importance. Fourteen (14) putative imprinted genes on bovine chromosome 29 (Bta 29) as well as the human (Hg 11) and mouse (Mm 7) orthologs were computationally characterized with respect to the CpG islands (CGI), transcription factor binding elements and sequence motif. Phylogenetic analysis was conducted across the three species for each of the genes identified to have promoter CGI. Promoter CGI were identified in ASCL2, TSSC4, CDKN1C, KCNQ1, PHLDA2 and NAP1L4. The promoter CGI were enriched with CpG containing transcription factor binding sites. Generally, it was observed that cattle was more closely related to human than mouse and that natural selection was the force driving the evolutionary change between the three species. Protein kinase motifs involved in phosphorylation were identified in the amino-acid sequences of ASCL2, TSSC4, PHLDA2 and NAP1L4. Our results suggest the post-translation regulation of imprinting and that the predicted promoter CGI can be assayed to determine molecular function, gene expression and DNA methylation status of the bovine putative imprinted genes.

Suggested Citation

  • Oladeji Bamidele & O. Omitogun & I. Imumorin, 2015. "DNA Sequence Characteristics and Phylogenetics of Putative Imprinted Genes on Bovine Chromosome 29," Journal of Agricultural Science, Canadian Center of Science and Education, vol. 7(8), pages 131-131, July.
  • Handle: RePEc:ibn:jasjnl:v:7:y:2015:i:8:p:131
    as

    Download full text from publisher

    File URL: https://ccsenet.org/journal/index.php/jas/article/download/46429/27371
    Download Restriction: no

    File URL: https://ccsenet.org/journal/index.php/jas/article/view/46429
    Download Restriction: no
    ---><---

    More about this item

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:ibn:jasjnl:v:7:y:2015:i:8:p:131. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Canadian Center of Science and Education (email available below). General contact details of provider: https://edirc.repec.org/data/cepflch.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.