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Suppression of Hepatitis B Virus Production and Inflammatory Response in vitro and in vivo by Mormodica charantia Compound EMCDO

Author

Listed:
  • Chi-I Chang
  • Chiy-Rong Chen
  • Yo-Chia Chen
  • Kuei-Wen Cheng
  • Bo-Wei Lin
  • Yun-Wen Liao
  • Wen-Ling Shih

Abstract

Eight compounds were purified from Mormodica charanti, and their chemical structures were determined in this study. Their anti-HBV and anti-inflammation activities were investigated. Compound EMCDO exhibited the most efficient effect in terms of reducing HBV surface antigen, e antigen and viral DNA levels in HBV particles or surface antigen-producing cells 2.2.15 and PLC/PRF/5, respectively. Tumor suppressor p53 played a significant role in EMCDO-mediated anti-HBV effects. Pretreatment with EMCDO prevented 2.2.15 cells-induced tumor formation in a nude mice subcutaneous model. The anti-HBV and anti-tumor activities of EMCDO were better than those of oltipraz, an inhibitor of HBV transcription. EMCDO reduced the proinflammatory cytokines and mediators in LPS-treated RAW264.7 cells in a dose-dependent manner. The LPS-upregulated phosphorylation level of Ika was reduced in the presence of EMCDO. The transcription activity of NF-kB was increased in cells treated with EMCDO. Utilization of a mouse ear edema model further confirmed the activity of EMCDO against TPA-elicited inflammation.

Suggested Citation

  • Chi-I Chang & Chiy-Rong Chen & Yo-Chia Chen & Kuei-Wen Cheng & Bo-Wei Lin & Yun-Wen Liao & Wen-Ling Shih, 2015. "Suppression of Hepatitis B Virus Production and Inflammatory Response in vitro and in vivo by Mormodica charantia Compound EMCDO," Journal of Agricultural Science, Canadian Center of Science and Education, vol. 7(4), pages 112-112, March.
    • Handle: RePEc:ibn:jasjnl:v:7:y:2015:i:4:p:112
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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