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Piper nigrum Fruit Extract Prevents TMA-Induced Allergic Contact Dermatitis by Regulating Th2 Cytokine Production

Author

Listed:
  • Sung Keun Jung
  • Dae Woon Choi
  • Chang Hwa Jung
  • Yang-Ji Kim
  • Sun Young Jung
  • Dong-Hwa Shon

Abstract

Allergic contact dermatitis (ACD) remains a leading skin disease in many countries. In this study, we investigated the preventive effect of Piper nigrum fruit extract (PFE) on trimellitic anhydride (TMA)-induced dermatitis and its potential mechanism of action. Oral administration of PFE and prednisolone (PS) significantly suppressed TMA-induced increases in ear, epidermal thickness, and infiltration of CD4+ cells, while abnormal expression of IgE, mMCP-1, IL-1B and IL-1B mRNA was also significantly counteracted by oral administration of PFE. PFE also significantly suppresses TMA-induced IL-4 and IL-5 production and IL-4 mRNA expression in vivo, as well as OVA-induced IL-4, IL-5, and IL-13 production and GATA3 mRNA expression ex vivo, and IL-4 induced STAT6 phosphorylation in primary cultured splenocytes and HaCaT cells. Interestingly, the PFE component piperine significantly suppressed OVA-induced IL-4, IL-5, and IL-13 secretion ex vivo. Taken together, these results suggest that PFE could be useful in suppressing allergic contact dermatitis.

Suggested Citation

  • Sung Keun Jung & Dae Woon Choi & Chang Hwa Jung & Yang-Ji Kim & Sun Young Jung & Dong-Hwa Shon, 2015. "Piper nigrum Fruit Extract Prevents TMA-Induced Allergic Contact Dermatitis by Regulating Th2 Cytokine Production," Journal of Agricultural Science, Canadian Center of Science and Education, vol. 7(2), pages 135-135, January.
    • Handle: RePEc:ibn:jasjnl:v:7:y:2015:i:2:p:135
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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