IDEAS home Printed from https://ideas.repec.org/a/ibn/gjhsjl/v8y2016i6p41.html
   My bibliography  Save this article

Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran

Author

Listed:
  • Mehrnoosh Maalhagh
  • Mohammad Shojaei
  • Saeideh Erfanian
  • Abdolreza Sotoodeh Jahromi
  • Mohammad Sadegh Sanie
  • Alireza Yusefi
  • Hassan Zabetian
  • Hossein Hakimelahi
  • Abdolhossien Madani
  • Mohammad Hojjat-Farsangi

Abstract

Tumor necrosis factor (TNF) is one of the inflammatory cytokines which has an important role in inflammation and migration of other inflammatory cells to the atherosclerotic plaques. OX40 is a member of the TNF super family receptor protein. OX40 and OX40 ligand are co-stimulators for T-cells and can increase inflammatory response in atherosclerotic plaques. The aim of this study was to determine the association of rs17568 polymorphism in OX40 gene with premature myocardial infarction. This case control study was done on 100 patients with premature acute myocardial infarction (AMI) and a similar number of sex, age and some other cardiovascular risk factor matched healthy people. The OX40 rs17568 polymorphism was genotyped, using PCR-RFLP method. A-allele frequency of rs17568 SNP was lower non-significantly in Premature AMI, compared to healthy subjects (49% vs. 51%). The analysis of rs17568 (A/G) polymorphism showed an odds ratio of 1.127 (95% CI- 0.635-1.999; P= 0.686) for the GG genotype and 5.761 (95% CI- 1.200-27.655; P= 0.029) for the AG genotype, compared to the AA genotype. The results of this study indicate that the rs17568 SNP of OX40 gene is not associated with premature AMI in the evaluated population.

Suggested Citation

  • Mehrnoosh Maalhagh & Mohammad Shojaei & Saeideh Erfanian & Abdolreza Sotoodeh Jahromi & Mohammad Sadegh Sanie & Alireza Yusefi & Hassan Zabetian & Hossein Hakimelahi & Abdolhossien Madani & Mohammad H, 2016. "Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran," Global Journal of Health Science, Canadian Center of Science and Education, vol. 8(6), pages 1-41, June.
    • Handle: RePEc:ibn:gjhsjl:v:8:y:2016:i:6:p:41
    as

    Download full text from publisher

    File URL: http://www.ccsenet.org/journal/index.php/gjhs/article/download/51848/28632
    Download Restriction: no
    File URL: http://www.ccsenet.org/journal/index.php/gjhs/article/view/51848
    Download Restriction: no
    ---><---

    More about this item

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:ibn:gjhsjl:v:8:y:2016:i:6:p:41. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Canadian Center of Science and Education (email available below). General contact details of provider: https://edirc.repec.org/data/cepflch.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.