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Assessment of Clinical and Laboratory Limits between Hashitoxicosis and Graves’ Disease

Author

Listed:
  • Juliana Delfino dos Reis
  • Taciana Carla Maia Feibelmann
  • Beatriz Pires Ferreira
  • Marcus Aurelho Lima
  • Janaíne Machado Tomé
  • Flávia Alves Ribeiro
  • Beatriz Hallal Jorge Lara
  • Maria de Fátima Borges

Abstract

BACKGROUND- Determine the clinical and laboratory features of Hashitoxicosis (Htx) and set standards that will help perform a differential diagnosis with Graves’Disease (GD). SUBJECTS & METHODS- we evaluated 45 patients with Htx (Hashi-group) diagnosed between January/1995 and July/2019 with autoimmune hyperthyroidism and cytology compatible with Hashimoto’s Thyroiditis (HT). The control group consisted of 51 patients with GD (Graves-group). RESULTS- clinical hyperthyroidism, free T4 (FT4), thyroid volume and need for antithyroid drugs were higher in the Graves-Group. Values of anti-thyroid antibodies and TSH were higher in the Hashi-Group. The definitive diagnostic criterion was cytology. Regarding the clinical course, 95% of the Hashi-Group had hyperthyroidism of short duration, while 84.3% of Graves-Group required radioactive iodine (RAI). CONCLUSION- hyperthyroidism due to HT was milder than that associated with GD. In most citology was able to distinguish HT from GD and predict spontaneous resolution preventing unnecessary RAI.

Suggested Citation

  • Juliana Delfino dos Reis & Taciana Carla Maia Feibelmann & Beatriz Pires Ferreira & Marcus Aurelho Lima & Janaíne Machado Tomé & Flávia Alves Ribeiro & Beatriz Hallal Jorge Lara & Maria de Fátima , 2022. "Assessment of Clinical and Laboratory Limits between Hashitoxicosis and Graves’ Disease," Global Journal of Health Science, Canadian Center of Science and Education, vol. 14(12), pages 1-28, December.
    • Handle: RePEc:ibn:gjhsjl:v:14:y:2022:i:12:p:28
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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