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Numerical Simulation of Solid Tumor Blood Perfusion and Drug Delivery during the “Vascular Normalization Window” with Antiangiogenic Therapy

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  • Jie Lv
  • Jin-feng Cao
  • Yan Cai
  • Yu Zhou
  • Quan Long
  • Wei Yao
  • Shi-xiong Xu

Abstract

To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled.

Suggested Citation

  • Jie Lv & Jin-feng Cao & Yan Cai & Yu Zhou & Quan Long & Wei Yao & Shi-xiong Xu, 2011. "Numerical Simulation of Solid Tumor Blood Perfusion and Drug Delivery during the “Vascular Normalization Window” with Antiangiogenic Therapy," Journal of Applied Mathematics, Hindawi, vol. 2011, pages 1-8, June.
    • Handle: RePEc:hin:jnljam:190371
    DOI: 10.1155/2011/190371
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