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A Schistosomiasis Model with Praziquantel Resistance

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  • Longxing Qi
  • Jing-an Cui

Abstract

A compartmental model is established for schistosomiasis with praziquantel resistance. The model considers the impact of genetic resistance and drug treatment on the transmission of schistosomiasis. We calculate the basic reproductive number and discuss the existence and stability of disease-free equilibrium, boundary equilibrium, and coexistence equilibrium. Our analysis shows that regardless of whether drug treatment leads to the emergence of resistance, once the impact of genetic resistance is larger, the resistant strain will be dominant, which is detrimental to the control of schistosomiasis. In addition, once the proportion of human with drug-resistant strain produced by drug treatment is larger, the number of human and snails with resistant strain is larger. This is not a good result for drug treatment with praziquantel.

Suggested Citation

  • Longxing Qi & Jing-an Cui, 2013. "A Schistosomiasis Model with Praziquantel Resistance," Discrete Dynamics in Nature and Society, Hindawi, vol. 2013, pages 1-13, March.
    • Handle: RePEc:hin:jnddns:945767
    DOI: 10.1155/2013/945767
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    Cited by:

    1. Pan Tang & Shiwen Qian & Lei Shi & Longxing Qi & Tingting Li, 2023. "The Influence of Migration to Regions with Different Coverages of Health Education on Schistosomiasis," Mathematics, MDPI, vol. 11(12), pages 1-27, June.

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