IDEAS home Printed from https://ideas.repec.org/a/hin/complx/4376279.html
   My bibliography  Save this article

Dynamical Analyses on Beta Oscillations in a STN-GPE-GPI Model of Parkinson’s Disease

Author

Listed:
  • Yuanhong Bi
  • Quansheng Liu
  • Jingyi Zhao
  • Wuritu Yang

Abstract

Exploring the behaviors of beta oscillations in the basal ganglia is helpful to understand the mechanism of Parkinson’s disease. Studies have shown that the external and internal segments (GPe, GPi) of the globus pallidus receive different intensities of signals from the striatum in Parkinson’s disease and play different roles in the production of beta oscillations, but the relevant mechanism still remains unclear. Based on a model of the subthalamic nucleus (STN) and globus pallidus (GP), we propose an extended STN-GPe-GPi model and analyze the dynamical behaviors of beta oscillations in this model. The stability condition is obtained through theoretical analyses, and the generation of beta oscillations by the inputs from the cortex and striatum is further considered. The influence of some parameters related to GPi on its firing rate oscillations is discussed. The results obtained in this paper are expected to play a guiding role in the medical treatment of Parkinson’s disease.

Suggested Citation

  • Yuanhong Bi & Quansheng Liu & Jingyi Zhao & Wuritu Yang, 2020. "Dynamical Analyses on Beta Oscillations in a STN-GPE-GPI Model of Parkinson’s Disease," Complexity, Hindawi, vol. 2020, pages 1-9, September.
    • Handle: RePEc:hin:complx:4376279
    DOI: 10.1155/2020/4376279
    as

    Download full text from publisher

    File URL: http://downloads.hindawi.com/journals/8503/2020/4376279.pdf
    Download Restriction: no
    File URL: http://downloads.hindawi.com/journals/8503/2020/4376279.xml
    Download Restriction: no
    File URL: https://libkey.io/10.1155/2020/4376279?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zeng, Qiaoyun & Zheng, Yanhong & Yi, Dan, 2024. "Bifurcation analysis of a Parkinson’s disease model with two time delays," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 219(C), pages 1-11.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hin:complx:4376279. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Mohamed Abdelhakeem (email available below). General contact details of provider: https://www.hindawi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.