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Exposure and Early Effect Biomarkers for Risk Assessment of Occupational Exposure to Formaldehyde: A Systematic Review

Author

Listed:
  • Carmela Protano

    (Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy)

  • Arianna Antonucci

    (Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy)

  • Andrea De Giorgi

    (Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy)

  • Stefano Zanni

    (Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy)

  • Elisa Mazzeo

    (Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy)

  • Vincenzo Cammalleri

    (Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy)

  • Leila Fabiani

    (Department of Life, Health and Environmental Sciences, University of L’Aquila, P.le Salvatore Tommasi 1, Coppito, 67100 L’Aquila, Italy)

  • Riccardo Mastrantonio

    (Department of Life, Health and Environmental Sciences, University of L’Aquila, P.le Salvatore Tommasi 1, Coppito, 67100 L’Aquila, Italy)

  • Mario Muselli

    (Department of Life, Health and Environmental Sciences, University of L’Aquila, P.le Salvatore Tommasi 1, Coppito, 67100 L’Aquila, Italy)

  • Giada Mastrangeli

    (Department of Life, Health and Environmental Sciences, University of L’Aquila, P.le Salvatore Tommasi 1, Coppito, 67100 L’Aquila, Italy)

  • Cinzia Lucia Ursini

    (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy)

  • Delia Cavallo

    (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy)

  • Diana Poli

    (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy)

  • Giorgia Di Gennaro

    (Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
    Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority-INAIL, Monte Porzio Catone, 00078 Rome, Italy)

  • Giuseppe De Palma

    (Unit of Occupational Health and Industrial Hygiene, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spdali Civili 1, 25123 Brescia, Italy)

  • Matteo Vitali

    (Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy)

Abstract

The aim of the present review was to identify all the biomarkers used for assessing the internal dose and the related early effects determined by the occupational exposure to formaldehyde. For this purpose, a systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The protocol was registered in PROSPERO (ID: CRD42023416960). An electronic search of Pubmed, Scopus, and Web of Science was performed to collect all the papers concerning the focus of the review and published from the inception of each database until 18 September 2023. Articles were considered eligible if they reported data from observational studies, semi-experimental, and experimental studies on adult workers who were occupationally exposed to formaldehyde, regardless of gender or age. The quality assessment was performed using the adapted Newcastle–Ottawa Quality Assessment Scale. From 1524 articles, 52 were included. Few studies assessed the exposure to formaldehyde in occupational settings through biomarkers, especially by measuring formic acid in urine. The most common approach for evaluating the effects derived from occupational exposure to formaldehyde was the use of the cytogenetic biomarker micronucleus assay in peripheral blood lymphocytes and/or epithelial buccal cells.

Suggested Citation

  • Carmela Protano & Arianna Antonucci & Andrea De Giorgi & Stefano Zanni & Elisa Mazzeo & Vincenzo Cammalleri & Leila Fabiani & Riccardo Mastrantonio & Mario Muselli & Giada Mastrangeli & Cinzia Lucia U, 2024. "Exposure and Early Effect Biomarkers for Risk Assessment of Occupational Exposure to Formaldehyde: A Systematic Review," Sustainability, MDPI, vol. 16(9), pages 1-19, April.
    • Handle: RePEc:gam:jsusta:v:16:y:2024:i:9:p:3631-:d:1383580
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    Cited by:

    1. Elena Barrese & Marco Valentini & Marialuisa Scarpelli & Pasquale Samele & Luana Malacaria & Francesco D’Amico & Teresa Lo Feudo, 2024. "Assessment of Formaldehyde’s Impact on Indoor Environments and Human Health via the Integration of Satellite Tropospheric Total Columns and Outdoor Ground Sensors," Sustainability, MDPI, vol. 16(22), pages 1-21, November.

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