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A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment

Author

Listed:
  • Rami Zakh

    (Department of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, Israel)

  • Alexander Churkin

    (Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 8410501, Israel)

  • William Bietsch

    (Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA)

  • Menachem Lachiany

    (Campus Lev, Jerusalem College of Technology, Jerusalem 91160, Israel)

  • Scott J. Cotler

    (Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA)

  • Alexander Ploss

    (Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA)

  • Harel Dahari

    (Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA)

  • Danny Barash

    (Department of Computer Science, Ben-Gurion University, Beer-Sheva 8410501, Israel)

Abstract

Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.

Suggested Citation

  • Rami Zakh & Alexander Churkin & William Bietsch & Menachem Lachiany & Scott J. Cotler & Alexander Ploss & Harel Dahari & Danny Barash, 2021. "A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment," Mathematics, MDPI, vol. 9(24), pages 1-9, December.
    • Handle: RePEc:gam:jmathe:v:9:y:2021:i:24:p:3323-:d:706663
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