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Anatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injury

Author

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  • Roman Rokeakh

    (Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
    Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 620049 Ekaterinburg, Russia
    Institute of Natural Sciences and Mathematics, Ural Federal University, 620075 Ekaterinburg, Russia
    These authors contributed equally to this work.)

  • Tatiana Nesterova

    (Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
    Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 620049 Ekaterinburg, Russia
    Institute of Natural Sciences and Mathematics, Ural Federal University, 620075 Ekaterinburg, Russia
    These authors contributed equally to this work.)

  • Konstantin Ushenin

    (Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 620049 Ekaterinburg, Russia
    Institute of Natural Sciences and Mathematics, Ural Federal University, 620075 Ekaterinburg, Russia)

  • Ekaterina Polyakova

    (Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia)

  • Dmitry Sonin

    (Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia)

  • Michael Galagudza

    (Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia)

  • Tim De Coster

    (Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

  • Alexander Panfilov

    (Almazov National Medical Research Centre, 197341 Saint-Petersburg, Russia
    Institute of Natural Sciences and Mathematics, Ural Federal University, 620075 Ekaterinburg, Russia
    Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Department of Physics and Astronomy, Ghent University, Krijgslaan 281, 9000 Gent, Belgium)

  • Olga Solovyova

    (Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences, 620049 Ekaterinburg, Russia
    Institute of Natural Sciences and Mathematics, Ural Federal University, 620075 Ekaterinburg, Russia)

Abstract

Species-specific computer models of the heart are a novel powerful tool in studies of life-threatening cardiac arrhythmias. Here, we develop such a model aimed at studying infarction injury in a rat heart, the most common experimental system to investigate the effects of myocardial damage. We updated the Gattoni2016 cellular ionic model by fitting its parameters to experimental data using a population modeling approach. Using four selected cellular models, we studied 2D spiral wave dynamics and found that they include meandering and break-up. Then, using an anatomically realistic ventricular geometry and fiber orientation in the rat heart, we built a model with a post-infarction scar to study the electrophysiological effects of myocardial damage. A post-infarction scar was simulated as an inexcitable obstacle surrounded by a border zone with modified cardiomyocyte properties. For cellular models, we studied the rotation of scroll waves and found that, depending on the model, we can observe different types of dynamics: anchoring, self-termination or stable rotation of the scroll wave. The observed arrhythmia characteristics coincide with those measured in the experiment. The developed model can be used to study arrhythmia in rat hearts with myocardial damage from ischemia reperfusion and to examine the possible arrhythmogenic effects of various experimental interventions.

Suggested Citation

  • Roman Rokeakh & Tatiana Nesterova & Konstantin Ushenin & Ekaterina Polyakova & Dmitry Sonin & Michael Galagudza & Tim De Coster & Alexander Panfilov & Olga Solovyova, 2021. "Anatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injury," Mathematics, MDPI, vol. 9(20), pages 1-27, October.
    • Handle: RePEc:gam:jmathe:v:9:y:2021:i:20:p:2604-:d:657695
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    References listed on IDEAS

    as
    1. Enid Van Nieuwenhuyse & Gunnar Seemann & Alexander V Panfilov & Nele Vandersickel, 2017. "Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-19, December.
    2. Nele Vandersickel & Ivan V Kazbanov & Anita Nuitermans & Louis D Weise & Rahul Pandit & Alexander V Panfilov, 2014. "A Study of Early Afterdepolarizations in a Model for Human Ventricular Tissue," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-19, January.
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    Cited by:

    1. Tatiana Nesterova & Roman Rokeakh & Olga Solovyova & Alexander Panfilov, 2023. "Mathematical Modelling of Leptin-Induced Effects on Electrophysiological Properties of Rat Cardiomyocytes and Cardiac Arrhythmias," Mathematics, MDPI, vol. 11(4), pages 1-15, February.

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