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The Potential Changes and Stereocilia Movements during the Cochlear Sound Perception Process

Author

Listed:
  • Bin Liu

    (School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China
    Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China)

  • Junyi Liang

    (Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44106, USA)

  • Wenjuan Yao

    (School of Mechanics and Engineering Science, Shanghai University, Shanghai 200072, China
    Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China)

  • Chun Xu

    (Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China)

Abstract

Sound vibrations generate electrical signals called cochlear potentials, which can reflect cochlear stereocilia movement and outer hair cells (OHC) mechanical activity. However, because the cochlear structure is delicate and complex, it is difficult for existing measurement techniques to pinpoint the origin of potentials. This limitation in measurement capability makes it difficult to fully understand the contribution of stereocilia and transduction channels to cochlear potentials. In view of this, firstly, this article obtains the stereocilia movement generated by basilar membrane (BM) vibration based on the positional relationship between the various structures of the organ Corti. Secondly, Kirchhoff’s law is used to establish an electric field model of the cochlear cavity, and the stereocilia movement is embedded in the electric field by combining the gated spring model. Finally, a force-electric coupling mathematical model of the cochlea is established. The results indicated that the resistance variation between different cavities in the cochlea leads to a sharp tuning curve. As the displacement of the BM increased, the longitudinal potential along the cochlea continued to move toward the base. The decrease in stereocilia stiffness reduced the deflection angle, thereby reducing the transduction current and lymphatic potential.

Suggested Citation

  • Bin Liu & Junyi Liang & Wenjuan Yao & Chun Xu, 2024. "The Potential Changes and Stereocilia Movements during the Cochlear Sound Perception Process," Mathematics, MDPI, vol. 12(16), pages 1-17, August.
    • Handle: RePEc:gam:jmathe:v:12:y:2024:i:16:p:2470-:d:1453706
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    References listed on IDEAS

    as
    1. H. J. Kennedy & A. C. Crawford & R. Fettiplace, 2005. "Force generation by mammalian hair bundles supports a role in cochlear amplification," Nature, Nature, vol. 433(7028), pages 880-883, February.
    2. David Z. Z. He & Shuping Jia & Peter Dallos, 2004. "Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea," Nature, Nature, vol. 429(6993), pages 766-770, June.
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