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A Mathematical Analysis of Competitive Dynamics and Aggressive Treatment in the Evolution of Drug Resistance in Malaria Parasites

Author

Listed:
  • Tianqi Song

    (School of Economics and Management, Shanghai Maritime University, Shanghai 201306, China)

  • Yishi Wang

    (Shanghai Institute of Aerospace System Engineering, Shanghai 201108, China)

  • Yang Li

    (School of Economics and Management, Shanghai Maritime University, Shanghai 201306, China)

  • Guoliang Fan

    (School of Economics and Management, Shanghai Maritime University, Shanghai 201306, China)

Abstract

Experimental evidence supports the counterintuitive notion that rapid eradication of pathogens within a host, infected with both drug-sensitive and -resistant malaria parasites, can actually accelerate the evolution of drug-resistant pathogens. This study aims to analyze the competitive dynamics between these two strains through a mathematical model and evaluate the impact of aggressive treatment on the spread of drug resistance. We conducted equilibrium, uncertainty, and sensitivity analyses to assess the model, identifying and measuring the influence of key factors on the outcome variable (the population of drug-resistant parasites). Both equilibrium and local sensitivity analyses concurred that the density of drug-resistant parasites is notably affected by genetic instability, the production rate of red blood cells, the number of merozoites, and competition factors. Conversely, there is a negative relationship between genetic instability and one of the competition coefficients. Global sensitivity analysis offers a comprehensive examination of the impact of each input parameter on the temporal propagation of drug resistance, effectively accounting for the interplay among parameters. Both local and global sensitivity analyses underscore the continuous impact of drug treatment on the progression of drug resistance over time. This paper anticipates exploring the underlying mechanisms of drug resistance and providing theoretical support for developing more effective drug treatment strategies.

Suggested Citation

  • Tianqi Song & Yishi Wang & Yang Li & Guoliang Fan, 2024. "A Mathematical Analysis of Competitive Dynamics and Aggressive Treatment in the Evolution of Drug Resistance in Malaria Parasites," Mathematics, MDPI, vol. 12(10), pages 1-16, May.
    • Handle: RePEc:gam:jmathe:v:12:y:2024:i:10:p:1595-:d:1398027
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    References listed on IDEAS

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    1. Chiyaka, Christinah & Garira, Winston & Dube, Shadreck, 2009. "Effects of treatment and drug resistance on the transmission dynamics of malaria in endemic areas," Theoretical Population Biology, Elsevier, vol. 75(1), pages 14-29.
    2. Chen, Hongyan & Wang, Wendi & Fu, Rui & Luo, Jianfeng, 2015. "Global analysis of a mathematical model on malaria with competitive strains and immune responses," Applied Mathematics and Computation, Elsevier, vol. 259(C), pages 132-152.
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