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Prediction of Parkinson’s Disease Depression Using LIME-Based Stacking Ensemble Model

Author

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  • Hung Viet Nguyen

    (Department of Digital Anti-Aging Healthcare (BK21), Inje University, Gimhae 50834, Republic of Korea)

  • Haewon Byeon

    (Department of Digital Anti-Aging Healthcare (BK21), Inje University, Gimhae 50834, Republic of Korea)

Abstract

Depression symptoms are comparable to Parkinson’s disease symptoms, including attention deficit, fatigue, and sleep disruption, as well as symptoms of dementia such as apathy. As a result, it is difficult for Parkinson’s disease caregivers to diagnose depression early. We examined a LIME-based stacking ensemble model to predict the depression of patients with Parkinson’s disease. This study used the epidemiologic data of Parkinson’s disease dementia patients (EPD) from the Korea Disease Control and Prevention Agency’s National Biobank, which included 526 patients’ information. We used Logistic Regression (LR) as the meta-model, and five base models, including LightGBM (LGBM), K-nearest Neighbors (KNN), Random Forest (RF), Extra Trees (ET), and AdaBoost. After cleansing the data, the stacking ensemble model was trained using 261 participants’ data and 10 variables. According to the research, the best combination of the stacking ensemble model is ET + LGBM + RF + LR, a harmonious model. In order to achieve model prediction explainability, we also combined the stacking ensemble model with a LIME-based explainable model. This explainable stacking ensemble model can help identify the patients and start treatment on them early in a way that medical professionals can comprehend.

Suggested Citation

  • Hung Viet Nguyen & Haewon Byeon, 2023. "Prediction of Parkinson’s Disease Depression Using LIME-Based Stacking Ensemble Model," Mathematics, MDPI, vol. 11(3), pages 1-13, January.
    • Handle: RePEc:gam:jmathe:v:11:y:2023:i:3:p:708-:d:1051903
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    References listed on IDEAS

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    1. Haewon Byeon, 2021. "Predicting the Severity of Parkinson’s Disease Dementia by Assessing the Neuropsychiatric Symptoms with an SVM Regression Model," IJERPH, MDPI, vol. 18(5), pages 1-9, March.
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    Cited by:

    1. Mukhtar, Roshana & Chang, Chuan-Yu & Raja, Muhammad Asif Zahoor & Chaudhary, Naveed Ishtiaq & Shu, Chi-Min, 2024. "Novel nonlinear fractional order Parkinson's disease model for brain electrical activity rhythms: Intelligent adaptive Bayesian networks," Chaos, Solitons & Fractals, Elsevier, vol. 180(C).

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