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Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients

Author

Listed:
  • Adequate Mhlanga

    (The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA
    These authors contributed equally to this work.)

  • Rami Zakh

    (Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel
    Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel
    These authors contributed equally to this work.)

  • Alexander Churkin

    (Department of Software Engineering, Sami Shamoon College of Engineering, Beer-Sheva 84108, Israel)

  • Vladimir Reinharz

    (Department of Computer Science, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada)

  • Jeffrey S. Glenn

    (Division of Gastroenterology and Hepatology, Departments of Medicine, Microbiology & Immunology, Stanford School of Medicine, Stanford, CA 94305, USA)

  • Ohad Etzion

    (Department of Gastroenterology and Liver Diseases, Soroka University Medical Center, Beer-Sheva 84101, Israel)

  • Scott J. Cotler

    (The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA)

  • Cihan Yurdaydin

    (Department of Gastroenterology and Hepatology, Koç University Medical School, Istanbul 34450, Turkey)

  • Danny Barash

    (Department of Computer Science, Ben-Gurion University, Beer-Sheva 84105, Israel)

  • Harel Dahari

    (The Program for Experimental and Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 84101, USA)

Abstract

Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.

Suggested Citation

  • Adequate Mhlanga & Rami Zakh & Alexander Churkin & Vladimir Reinharz & Jeffrey S. Glenn & Ohad Etzion & Scott J. Cotler & Cihan Yurdaydin & Danny Barash & Harel Dahari, 2022. "Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients," Mathematics, MDPI, vol. 10(20), pages 1-13, October.
    • Handle: RePEc:gam:jmathe:v:10:y:2022:i:20:p:3917-:d:949971
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