IDEAS home Printed from https://ideas.repec.org/a/gam/jmathe/v10y2022i18p3375-d917199.html
   My bibliography  Save this article

Mixture Modeling of Time-to-Event Data in the Proportional Odds Model

Author

Listed:
  • Xifen Huang

    (School of Mathematics, Yunnan Normal University, Kunming 650092, China)

  • Chaosong Xiong

    (School of Mathematics, Yunnan Normal University, Kunming 650092, China)

  • Jinfeng Xu

    (School of Mathematics, Minnan Normal University, Zhangzhou 363000, China)

  • Jianhua Shi

    (School of Mathematics, Minnan Normal University, Zhangzhou 363000, China)

  • Jinhong Huang

    (School of Mathematics, Minnan Normal University, Zhangzhou 363000, China)

Abstract

Subgroup analysis with survival data are most essential for detailed assessment of the risks of medical products in heterogeneous population subgroups. In this paper, we developed a semiparametric mixture modeling strategy in the proportional odds model for simultaneous subgroup identification and regression analysis of survival data that flexibly allows the covariate effects to differ among several subgroups. Neither the membership or the subgroup-specific covariate effects are known a priori. The nonparametric maximum likelihood method together with a pair of MM algorithms with monotone ascent property are proposed to carry out the estimation procedures. Then, we conducted two series of simulation studies to examine the finite sample performance of the proposed estimation procedure. An empirical analysis of German breast cancer data is further provided for illustrating the proposed methodology.

Suggested Citation

  • Xifen Huang & Chaosong Xiong & Jinfeng Xu & Jianhua Shi & Jinhong Huang, 2022. "Mixture Modeling of Time-to-Event Data in the Proportional Odds Model," Mathematics, MDPI, vol. 10(18), pages 1-11, September.
    • Handle: RePEc:gam:jmathe:v:10:y:2022:i:18:p:3375-:d:917199
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2227-7390/10/18/3375/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2227-7390/10/18/3375/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Ruo-fan Wu & Ming Zheng & Wen Yu, 2016. "Subgroup Analysis with Time-to-Event Data Under a Logistic-Cox Mixture Model," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 43(3), pages 863-878, September.
    2. Yingwei Peng & Keith B. G. Dear, 2000. "A Nonparametric Mixture Model for Cure Rate Estimation," Biometrics, The International Biometric Society, vol. 56(1), pages 237-243, March.
    3. L. Altstein & G. Li, 2013. "Latent Subgroup Analysis of a Randomized Clinical Trial through a Semiparametric Accelerated Failure Time Mixture Model," Biometrics, The International Biometric Society, vol. 69(1), pages 52-61, March.
    4. Juan Shen & Xuming He, 2015. "Inference for Subgroup Analysis With a Structured Logistic-Normal Mixture Model," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 110(509), pages 303-312, March.
    5. David Hunter & Kenneth Lange, 2002. "Computing Estimates in the Proportional Odds Model," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 54(1), pages 155-168, March.
    6. Green P.J. & Richardson S., 2002. "Hidden Markov Models and Disease Mapping," Journal of the American Statistical Association, American Statistical Association, vol. 97, pages 1055-1070, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xifen Huang & Jinfeng Xu, 2022. "Subgroup Identification and Regression Analysis of Clustered and Heterogeneous Interval-Censored Data," Mathematics, MDPI, vol. 10(6), pages 1-11, March.
    2. Shengli An & Peter Zhang & Hong-Bin Fang, 2023. "Subgroup Identification in Survival Outcome Data Based on Concordance Probability Measurement," Mathematics, MDPI, vol. 11(13), pages 1-10, June.
    3. Peng Jin & Wenbin Lu & Yu Chen & Mengling Liu, 2023. "Change‐plane analysis for subgroup detection with a continuous treatment," Biometrics, The International Biometric Society, vol. 79(3), pages 1920-1933, September.
    4. Pei, Youquan & Peng, Heng & Xu, Jinfeng, 2024. "A latent class Cox model for heterogeneous time-to-event data," Journal of Econometrics, Elsevier, vol. 239(2).
    5. Narisetty, Naveen & Koenker, Roger, 2022. "Censored quantile regression survival models with a cure proportion," Journal of Econometrics, Elsevier, vol. 226(1), pages 192-203.
    6. Wentian Guo & Yuan Ji & Daniel V. T. Catenacci, 2017. "A subgroup cluster-based Bayesian adaptive design for precision medicine," Biometrics, The International Biometric Society, vol. 73(2), pages 367-377, June.
    7. Spezia, L. & Cooksley, S.L. & Brewer, M.J. & Donnelly, D. & Tree, A., 2014. "Modelling species abundance in a river by Negative Binomial hidden Markov models," Computational Statistics & Data Analysis, Elsevier, vol. 71(C), pages 599-614.
    8. Xu, Linzhi & Zhang, Jiajia, 2010. "Multiple imputation method for the semiparametric accelerated failure time mixture cure model," Computational Statistics & Data Analysis, Elsevier, vol. 54(7), pages 1808-1816, July.
    9. Chen, Chyong-Mei & Lu, Tai-Fang C., 2012. "Marginal analysis of multivariate failure time data with a surviving fraction based on semiparametric transformation cure models," Computational Statistics & Data Analysis, Elsevier, vol. 56(3), pages 645-655.
    10. Ortega, Edwin M.M. & Cordeiro, Gauss M. & Lemonte, Artur J., 2012. "A log-linear regression model for the β-Birnbaum–Saunders distribution with censored data," Computational Statistics & Data Analysis, Elsevier, vol. 56(3), pages 698-718.
    11. Luigi Spezia, 2019. "Modelling covariance matrices by the trigonometric separation strategy with application to hidden Markov models," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 28(2), pages 399-422, June.
    12. Guoqing Diao & Ao Yuan, 2019. "A class of semiparametric cure models with current status data," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 25(1), pages 26-51, January.
    13. Ana López-Cheda & Yingwei Peng & María Amalia Jácome, 2023. "Nonparametric estimation in mixture cure models with covariates," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 32(2), pages 467-495, June.
    14. Li, Chin-Shang & Taylor, Jeremy M. G. & Sy, Judy P., 2001. "Identifiability of cure models," Statistics & Probability Letters, Elsevier, vol. 54(4), pages 389-395, October.
    15. Mengling Liu & Wenbin Lu & Yongzhao Shao, 2006. "Interval Mapping of Quantitative Trait Loci for Time-to-Event Data with the Proportional Hazards Mixture Cure Model," Biometrics, The International Biometric Society, vol. 62(4), pages 1053-1061, December.
    16. Bremhorst, Vincent & Lambert, Philippe, 2016. "Flexible estimation in cure survival models using Bayesian P-splines," Computational Statistics & Data Analysis, Elsevier, vol. 93(C), pages 270-284.
    17. Na You & Shun He & Xueqin Wang & Junxian Zhu & Heping Zhang, 2018. "Subtype classification and heterogeneous prognosis model construction in precision medicine," Biometrics, The International Biometric Society, vol. 74(3), pages 814-822, September.
    18. Wang, Wuyi & Su, Liangjun, 2021. "Identifying latent group structures in nonlinear panels," Journal of Econometrics, Elsevier, vol. 220(2), pages 272-295.
    19. López-Cheda, Ana & Cao, Ricardo & Jácome, M. Amalia & Van Keilegom, Ingrid, 2017. "Nonparametric incidence estimation and bootstrap bandwidth selection in mixture cure models," Computational Statistics & Data Analysis, Elsevier, vol. 105(C), pages 144-165.
    20. Yi-Hsuan Lee & Zhiliang Ying, 2015. "A Mixture Cure-Rate Model for Responses and Response Times in Time-Limit Tests," Psychometrika, Springer;The Psychometric Society, vol. 80(3), pages 748-775, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jmathe:v:10:y:2022:i:18:p:3375-:d:917199. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.