Author
Listed:
- Sofia Magalhães
(Department of Biomedicine, Faculty of Medicine of University of Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Superior Institute of Engineering of Porto (ISEP), Polytechnic of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal)
- Carla Luís
(Department of Biomedicine, Faculty of Medicine of University of Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Institute of Investigation and Innovation in Health (I3S), Rua Alfredo Allen, 208, 4200-135 Porto, Portugal
School of Medicine and Biomedical Sciences, Fernando Pessoa University (EMCB/UFP), Praça de 9 de Abril 349, 4249-004 Porto, Portugal)
- Abel Duarte
(Superior Institute of Engineering of Porto (ISEP), Polytechnic of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal
REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal
Center of Innovation in Engineering and Industrial Technology, ISEP, Polytechnic of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal)
Abstract
This study explored a novel method using fructose-derived carbon dots (FCDs) for antitumor therapy in breast cancer (BC), marking a pioneering use of fructose as a carbon source for nanoparticle synthesis. BC, known for its complexity and heterogeneity, was chosen as a model due to its increasing mortality and incidence rates. The FCD synthesis involved the decomposition of fructose through microwave irradiation, followed by purification and characterization using techniques such as transmission electron microscopy, dynamic light scattering, fluorescence spectrophotometry, and Fourier-transform infrared spectroscopy. The FCDs, ranging in size from 2 to 6 nm, presented a hydrodynamic diameter below 2 nm, a spherical morphology, and a crystalline structure. As expected, FCDs were composed by carbon, oxygen, and hydrogen, and exhibited fluorescence with absorption and emission spectra at 405 nm and around 520 nm, respectively. Cell-based assays on breast epithelial and tumor cell lines demonstrated a dose-dependent response, with a decreased viability rate more pronounced in breast tumor cells. In conclusion, FCDs showed significant potential as selective antitumor agents for breast cancer therapy. The comprehensive characterization and cell-based assay evaluations provided valuable insights into the applications of these nanoparticles in breast cancer treatment, highlighting their selective toxicity and impact on tumor cells.
Suggested Citation
Sofia Magalhães & Carla Luís & Abel Duarte, 2024.
"Fructose-Derived Carbon Dots as Selective Antitumor Agents in Breast Cancer Therapy: Synthesis, Characterization, and Biological Evaluation,"
J, MDPI, vol. 7(4), pages 1-8, December.
Handle:
RePEc:gam:jjopen:v:7:y:2024:i:4:p:35-591:d:1549727
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