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Malignant Transformation of Rat Kidney Induced by Environmental Substances and Estrogen

Author

Listed:
  • Susana Alfaro-Lira

    (Instituto de Alta Investigación, Universidad de Tarapacá, Calle Antofagasta 1520, Arica, Chile)

  • María Pizarro-Ortiz

    (Instituto de Alta Investigación, Universidad de Tarapacá, Calle Antofagasta 1520, Arica, Chile)

  • Gloria M. Calaf

    (Instituto de Alta Investigación, Universidad de Tarapacá, Calle Antofagasta 1520, Arica, Chile
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA)

Abstract

The use of organophosphorous insecticides in agricultural environments and in urban settings has increased significantly. The aim of the present study was to analyze morphological alterations induced by malathion and 17β-estradiol (estrogen) in rat kidney tissues. There were four groups of animals: control, malathion, estrogen and combination of both substances. The animals were injected for five days and sacrificed 30, 124 and 240 days after treatments. Kidney tissues were analyzed for histomorphological and immunocytochemical alterations. Morphometric analysis indicated that malathion plus estrogen-treated animals showed a significantly ( p

Suggested Citation

  • Susana Alfaro-Lira & María Pizarro-Ortiz & Gloria M. Calaf, 2012. "Malignant Transformation of Rat Kidney Induced by Environmental Substances and Estrogen," IJERPH, MDPI, vol. 9(5), pages 1-19, May.
    • Handle: RePEc:gam:jijerp:v:9:y:2012:i:5:p:1630-1648:d:17552
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