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Protective Effect of Anthocyanins from Lingonberry on Radiation-induced Damages

Author

Listed:
  • Zi-Luan Fan

    (School of Forestry, Northeast Forestry University, 26 HeXing Road, XiangFang District, Harbin 150040, China)

  • Zhen-Yu Wang

    (School of Forestry, Northeast Forestry University, 26 HeXing Road, XiangFang District, Harbin 150040, China
    School of Food Science and Engineering, Harbin Institute of Technology, 73 HuangHe Road, NanGang District, Harbin 150090, China)

  • Li-Li Zuo

    (School of Food Science and Engineering, Harbin Institute of Technology, 73 HuangHe Road, NanGang District, Harbin 150090, China)

  • Shuang-Qi Tian

    (College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China)

Abstract

There is a growing concern about the serious harm of radioactive materials, which are widely used in energy production, scientific research, medicine, industry and other areas. In recent years, owing to the great side effects of anti-radiation drugs, research on the radiation protectants has gradually expanded from the previous chemicals to the use of natural anti-radiation drugs and functional foods. Some reports have confirmed that anthocyanins are good antioxidants, which can effectively eliminate free radicals, but studies on the immunoregulatory and anti-radiation effects of anthocyanins from lingonberry (ALB) are less reported. In this experiment, mice were given orally once daily for 14 consecutive days before exposure to 6 Gy of gamma-radiation and were sacrificed on the 7th day post-irradiation. The results showed that the selected dose of extract did not lead to acute toxicity in mice; while groups given anthocyanins orally were significantly better than radiation control group according to blood analysis; pretreatment of anthocyanins significantly ( p < 0.05) enhanced the thymus and spleen indices and spleen cell survival compared to the irradiation control group. Pretreatment with anthocyanins before irradiation significantly reduced the numbers of micronuclei (MN) in bone marrow polychromatic erythrocytes (PCEs). These findings indicate that anthocyanins have immunostimulatory potential against immunosuppression induced by the radiation.

Suggested Citation

  • Zi-Luan Fan & Zhen-Yu Wang & Li-Li Zuo & Shuang-Qi Tian, 2012. "Protective Effect of Anthocyanins from Lingonberry on Radiation-induced Damages," IJERPH, MDPI, vol. 9(12), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:9:y:2012:i:12:p:4732-4743:d:22279
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    Cited by:

    1. Yabin Duan & Fan Chen & Xingchen Yao & Junbo Zhu & Cai Wang & Juanling Zhang & Xiangyang Li, 2015. "Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice," IJERPH, MDPI, vol. 12(7), pages 1-16, July.
    2. Zhuo Zhang & Bo Zhou & Hiaohong Wang & Fei Wang & Yingli Song & Shengnan Liu & Shuhua Xi, 2014. "Maize Purple Plant Pigment Protects Against Fluoride-Induced Oxidative Damage of Liver and Kidney in Rats," IJERPH, MDPI, vol. 11(1), pages 1-14, January.

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