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Fumonisin B 1 Toxicity in Grower-Finisher Pigs: A Comparative Analysis of Genetically Engineered Bt Corn and non-Bt Corn by Using Quantitative Dietary Exposure Assessment Modeling

Author

Listed:
  • James E. Delgado

    (Interdepartmental Toxicology Program, Department of Agronomy, Iowa State University, Ames, IA 50011, USA)

  • Jeffrey D. Wolt

    (Interdepartmental Toxicology Program, Department of Agronomy, Iowa State University, Ames, IA 50011, USA)

Abstract

In this study, we investigate the long-term exposure (20 weeks) to fumonisin B 1 (FB 1 ) in grower-finisher pigs by conducting a quantitative exposure assessment (QEA). Our analytical approach involved both deterministic and semi-stochastic modeling for dietary comparative analyses of FB 1 exposures originating from genetically engineered Bacillus thuringiensis (Bt)-corn, conventional non-Bt corn and distiller’s dried grains with solubles (DDGS) derived from Bt and/or non-Bt corn. Results from both deterministic and semi-stochastic demonstrated a distinct difference of FB 1 toxicity in feed between Bt corn and non-Bt corn. Semi-stochastic results predicted the lowest FB 1 exposure for Bt grain with a mean of 1.5 mg FB 1 /kg diet and the highest FB 1 exposure for a diet consisting of non-Bt grain and non-Bt DDGS with a mean of 7.87 mg FB 1 /kg diet; the chronic toxicological incipient level of concern is 1.0 mg of FB 1 /kg of diet. Deterministic results closely mirrored but tended to slightly under predict the mean result for the semi-stochastic analysis. This novel comparative QEA model reveals that diet scenarios where the source of grain is derived from Bt corn presents less potential to induce FB 1 toxicity than diets containing non-Bt corn.

Suggested Citation

  • James E. Delgado & Jeffrey D. Wolt, 2011. "Fumonisin B 1 Toxicity in Grower-Finisher Pigs: A Comparative Analysis of Genetically Engineered Bt Corn and non-Bt Corn by Using Quantitative Dietary Exposure Assessment Modeling," IJERPH, MDPI, vol. 8(8), pages 1-12, July.
    • Handle: RePEc:gam:jijerp:v:8:y:2011:i:8:p:3179-3190:d:13346
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