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Genotoxic Effect of Chronic Exposure to DDT on Lymphocytes, Oral Mucosa and Breast Cells of Female Rats

Author

Listed:
  • Alejandro Canales-Aguirre

    (Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of Jalisco, A.C. (CIATEJ), Normalistas 800, Guadalajara, 44270, Mexico)

  • Eduardo Padilla-Camberos

    (Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of Jalisco, A.C. (CIATEJ), Normalistas 800, Guadalajara, 44270, Mexico)

  • Ulises Gómez-Pinedo

    (Laboratory of Regenerative Medicine, Neuroscience Institute, Hospital Clinico San Carlos, Madrid, 28040, Spain)

  • Hugo Salado-Ponce

    (Unit of Medical and Pharmaceutical Biotechnology, Center for Research and Assistance in Technology and Design of Jalisco, A.C. (CIATEJ), Normalistas 800, Guadalajara, 44270, Mexico)

  • Alfredo Feria-Velasco

    (Biological Sciences Department, Biological and Agricultural Sciences Center, University of Guadalajara, Carr. a Nogales Km 15.5, Zapopan, 45110, Mexico
    BiosMedica Cancer Research Institute, Alcatraces 72, Jardin Real, Zapopan, 45136, Mexico)

  • Ruth De Celis

    (BiosMedica Cancer Research Institute, Alcatraces 72, Jardin Real, Zapopan, 45136, Mexico
    Environmental Immunology Laboratory, Western Biomedical Research Center of the Mexican, Institute for Social Security, Sierra Mojada 800, Colonia Independencia, S.L., Guadalajara, 44340, Mexico)

Abstract

The genotoxicity of some environmental contaminants may affect human health directly by damaging genetic material and thus plays an important role in cancer development. Xenoestrogens are one kind of environmental pollutants that may alter hormonal routes or directly affect DNA. The number of available biomarkers used to assess genetic risk and cancer is very extensive. The present study evaluated genotoxicity produced by the pesticide DDT on systemic and mammary gland cells obtained from adult female Wistar rats. Oral mucosa cells micronuclei were assessed; the comet assay in peripheral blood-isolated lymphocytes and mammary epithelial cells was also carried out. Additionally, oxidative stress was studied in mammary tissue through a lipid peroxidation assay. Our data showed an increase in lipid peroxidation, product of an increase in free oxygen radical levels, which leads to an oxidative stress status. Our results suggest that DDT is genotoxic, not only for lymphocytes but also to mammary epithelial cells.

Suggested Citation

  • Alejandro Canales-Aguirre & Eduardo Padilla-Camberos & Ulises Gómez-Pinedo & Hugo Salado-Ponce & Alfredo Feria-Velasco & Ruth De Celis, 2011. "Genotoxic Effect of Chronic Exposure to DDT on Lymphocytes, Oral Mucosa and Breast Cells of Female Rats," IJERPH, MDPI, vol. 8(2), pages 1-14, February.
    • Handle: RePEc:gam:jijerp:v:8:y:2011:i:2:p:540-553:d:11385
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    Cited by:

    1. Xinxin Huang & Yuanyuan Li & Tantan Wang & Hui Liu & Jiaqi Shi & Xuesheng Zhang, 2020. "Evaluation of the Oxidative Stress Status in Zebrafish ( Danio rerio ) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA)," IJERPH, MDPI, vol. 17(2), pages 1-13, January.

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