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Related Factors of Insulin Resistance in Korean Children: Adiposity and Maternal Insulin Resistance

Author

Listed:
  • Young-Gyu Cho

    (Department of Family Medicine, Seoul-Paik Hospital, College of Medicine, Inje University, 85 Jeo-dong 2-ga, Jung-gu, Seoul 100032, Korea
    Institute of Clinical Nutrition, Inje University, 85 Jeo-dong 2-ga, Jung-gu, Seoul 100032, Korea)

  • Jae-Heon Kang

    (Department of Family Medicine, Seoul-Paik Hospital, College of Medicine, Inje University, 85 Jeo-dong 2-ga, Jung-gu, Seoul 100032, Korea
    Institute of Clinical Nutrition, Inje University, 85 Jeo-dong 2-ga, Jung-gu, Seoul 100032, Korea)

  • Yang-Im Hur

    (Department of Family Medicine, Seoul-Paik Hospital, College of Medicine, Inje University, 85 Jeo-dong 2-ga, Jung-gu, Seoul 100032, Korea
    Institute of Clinical Nutrition, Inje University, 85 Jeo-dong 2-ga, Jung-gu, Seoul 100032, Korea)

  • Jihyun Song

    (Division of Metabolic Diseases, Center for Biomedical Sciences, National Institute of Health, 187 Osongsaengmyeong 2-ro, Gangoe-myeon, Cheongwon-gun, Chungcheongbuk-do 363951, Korea)

  • Kang-Sook Lee

    (Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Banpo-dong, Seocho-gu, Seoul 137-701, Korea)

Abstract

Increased adiposity and unhealthy lifestyle augment the risk for type 2 diabetes in children with familial predisposition. Insulin resistance (IR) is an excellent clinical marker for identifying children at high risk for type 2 diabetes. This study was conducted to investigate parental, physiological, behavioral and socio-economic factors related to IR in Korean children. This study is a cross-sectional study using data from 111 children aged 7 years and their parents. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated using fasting glucose and insulin level as a marker of IR. All children’s adiposity indices ( r = 0.309–0.318, all P -value = 0.001) and maternal levels of fasting insulin ( r = 0.285, P -value = 0.003) and HOMA-IR ( r = 0.290, P -value = 0.002) were positively correlated with children’s HOMA-IR level. There was no statistical difference of children’s HOMA-IR level according to children’s lifestyle habits and socioeconomic status of families. An increase of 1 percentage point in body fat was related to 2.7% increase in children’s HOMA-IR ( P -value P -value = 0.002). This study shows that children’s adiposity and maternal IR are positively associated with children’s IR.

Suggested Citation

  • Young-Gyu Cho & Jae-Heon Kang & Yang-Im Hur & Jihyun Song & Kang-Sook Lee, 2011. "Related Factors of Insulin Resistance in Korean Children: Adiposity and Maternal Insulin Resistance," IJERPH, MDPI, vol. 8(12), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:8:y:2011:i:12:p:4596-4607:d:15182
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