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Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood

Author

Listed:
  • Steven D. Holladay

    (Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA)

  • Shuo Xiao

    (Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
    Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA)

  • Honglu Diao

    (Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
    Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA)

  • Jamie Barber

    (Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA)

  • Tomas Nagy

    (Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA)

  • Xiaoqin Ye

    (Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
    Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA)

  • Robert M. Gogal

    (Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA)

Abstract

Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of T H 1 up-regulation more than T H 2, and with skewing toward T H 17 responses.

Suggested Citation

  • Steven D. Holladay & Shuo Xiao & Honglu Diao & Jamie Barber & Tomas Nagy & Xiaoqin Ye & Robert M. Gogal, 2010. "Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood," IJERPH, MDPI, vol. 7(7), pages 1-8, July.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:7:p:2845-2852:d:8948
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