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Chelation in Metal Intoxication

Author

Listed:
  • Swaran J.S. Flora

    (Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India)

  • Vidhu Pachauri

    (Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India)

Abstract

Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals. Chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. 2,3-Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, however its serious side effects have led researchers to develop less toxic analogues. Hydrophilic chelators like meso -2,3-dimercaptosuccinic acid effectively promote renal metal excretion, but their ability to access intracellular metals is weak. Newer strategies to address these drawbacks like combination therapy (use of structurally different chelating agents) or co-administration of antioxidants have been reported recently. In this review we provide an update of the existing chelating agents and the various strategies available for the treatment of heavy metals and metalloid intoxications.

Suggested Citation

  • Swaran J.S. Flora & Vidhu Pachauri, 2010. "Chelation in Metal Intoxication," IJERPH, MDPI, vol. 7(7), pages 1-44, June.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:7:p:2745-2788:d:8800
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    Cited by:

    1. Paula Nobre & Maria de Fátima Cabral & Judite Costa & Margarida Castro-Caldas & Cristina Carvalho & Vasco Branco, 2019. "In Vitro Assessment of the Efficacy of a Macrocyclic Chelator in Reversing Methylmercury Toxicity," IJERPH, MDPI, vol. 16(23), pages 1-11, November.
    2. Amelia Geraldine Peregrina-Chávez & María Del Rayo Ramírez-Galindo & Rolando Chávez-Martínez & Cesar Anuar Delahanty-Delgado & Fernando Vazquez-Alaniz, 2018. "Full Atrioventricular Block Secondary to Acute Poisoning Mercury: A Case Report," IJERPH, MDPI, vol. 15(4), pages 1-9, April.
    3. Giuseppe Genchi & Maria Stefania Sinicropi & Graziantonio Lauria & Alessia Carocci & Alessia Catalano, 2020. "The Effects of Cadmium Toxicity," IJERPH, MDPI, vol. 17(11), pages 1-24, May.

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