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Maternal Diet, Behaviour and Offspring Skeletal Health

Author

Listed:
  • Laura R. Goodfellow

    (Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK)

  • Susannah Earl

    (Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK)

  • Cyrus Cooper

    (Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK)

  • Nicholas C. Harvey

    (Medical Research Council Epidemiology Resource Centre, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK)

Abstract

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.

Suggested Citation

  • Laura R. Goodfellow & Susannah Earl & Cyrus Cooper & Nicholas C. Harvey, 2010. "Maternal Diet, Behaviour and Offspring Skeletal Health," IJERPH, MDPI, vol. 7(4), pages 1-13, April.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:4:p:1760-1772:d:7983
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    Cited by:

    1. Adam Benjamin Rohrlach & Maïté Rivollat & Patxuka de-Miguel-Ibáñez & Ulla Moilanen & Anne-Mari Liira & João C. Teixeira & Xavier Roca-Rada & Javier Armendáriz-Martija & Kamen Boyadzhiev & Yavor Boyadz, 2024. "Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA," Nature Communications, Nature, vol. 15(1), pages 1-8, December.

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