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A Multidisciplinary Investigation of a Polycythemia Vera Cancer Cluster of Unknown Origin

Author

Listed:
  • Vincent Seaman

    (Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA, 30341, USA)

  • Steve M. Dearwent

    (Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA, 30341, USA)

  • Debra Gable

    (Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA, 30341, USA)

  • Brian Lewis

    (Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA, 30341, USA)

  • Susan Metcalf

    (Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA, 30341, USA)

  • Ken Orloff

    (Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA, 30341, USA)

  • Bruce Tierney

    (Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA, 30341, USA)

  • Jane Zhu

    (Agency for Toxic Substances and Disease Registry, 4770 Buford Highway NE, Atlanta, GA, 30341, USA)

  • James Logue

    (Pennsylvania Department of Health, 7th & Forster Streets, Harrisburg, PA 17120, USA)

  • David Marchetto

    (Pennsylvania Department of Health, 7th & Forster Streets, Harrisburg, PA 17120, USA)

  • Stephen Ostroff

    (Pennsylvania Department of Health, 7th & Forster Streets, Harrisburg, PA 17120, USA)

  • Ronald Hoffman

    (Mt. Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA)

  • Mingjiang Xu

    (Mt. Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA)

  • David Carey

    (Geisinger Health System/Clinic, 100 N. Academy Ave, Danville, PA 17822, USA)

  • Porat Erlich

    (Geisinger Health System/Clinic, 100 N. Academy Ave, Danville, PA 17822, USA)

  • Glenn Gerhard

    (Geisinger Health System/Clinic, 100 N. Academy Ave, Danville, PA 17822, USA)

  • Paul Roda

    (Geisinger Health System/Clinic, 100 N. Academy Ave, Danville, PA 17822, USA)

  • Joseph Iannuzzo

    (Pennsylvania Department of Environmental Protection, 2 Public Square, Wilkes-Barre, PA 18711, USA)

  • Robert Lewis

    (Pennsylvania Department of Environmental Protection, 2 Public Square, Wilkes-Barre, PA 18711, USA)

  • John Mellow

    (Pennsylvania Department of Environmental Protection, 2 Public Square, Wilkes-Barre, PA 18711, USA)

  • Linda Mulvihill

    (Centers for Disease Control and Prevention, National Program of Cancer Registries, 1600 Clifton, Rd NE, Atlanta, GA 30333, USA)

  • Zachary Myles

    (Centers for Disease Control and Prevention, National Program of Cancer Registries, 1600 Clifton, Rd NE, Atlanta, GA 30333, USA)

  • Manxia Wu

    (Centers for Disease Control and Prevention, National Program of Cancer Registries, 1600 Clifton, Rd NE, Atlanta, GA 30333, USA)

  • Arthur Frank

    (Drexel University School of Public Health, 1505 Race Street, Bellet Building 13th Floor, Philadelphia, PA, 19102, USA)

  • Carol Ann Gross-Davis

    (Drexel University School of Public Health, 1505 Race Street, Bellet Building 13th Floor, Philadelphia, PA, 19102, USA)

  • Judith Klotz

    (Drexel University School of Public Health, 1505 Race Street, Bellet Building 13th Floor, Philadelphia, PA, 19102, USA)

  • Adam Lynch

    (Drexel University School of Public Health, 1505 Race Street, Bellet Building 13th Floor, Philadelphia, PA, 19102, USA)

  • Joel Weissfeld

    (UPMC Cancer Pavilion, 3rd Floor, 5150 Centre Avenue, Pittsburgh, PA 15232, USA)

  • Rona Weinberg

    (New York Blood Center, 310 East 67th Street, 2-47B, New York, NY 10065, USA)

  • Henry Cole

    (Henry S. Cole & Associates, 7611 S. Osborne Rd, Ste 201, Upper Marlboro, MD 20772, USA)

Abstract

Cancer cluster investigations rarely receive significant public health resource allocations due to numerous inherent challenges and the limited success of past efforts. In 2008, a cluster of polycythemia vera, a rare blood cancer with unknown etiology, was identified in northeast Pennsylvania. A multidisciplinary group of federal and state agencies, academic institutions, and local healthcare providers subsequently developed a multifaceted research portfolio designed to better understand the cause of the cluster. This research agenda represents a unique and important opportunity to demonstrate that cancer cluster investigations can produce desirable public health and scientific outcomes when necessary resources are available.

Suggested Citation

  • Vincent Seaman & Steve M. Dearwent & Debra Gable & Brian Lewis & Susan Metcalf & Ken Orloff & Bruce Tierney & Jane Zhu & James Logue & David Marchetto & Stephen Ostroff & Ronald Hoffman & Mingjiang Xu, 2010. "A Multidisciplinary Investigation of a Polycythemia Vera Cancer Cluster of Unknown Origin," IJERPH, MDPI, vol. 7(3), pages 1-14, March.
    • Handle: RePEc:gam:jijerp:v:7:y:2010:i:3:p:1139-1152:d:7501
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