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Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity

Author

Listed:
  • Nadja Chumaeva

    (Department of Psychology, University of Helsinki, P.O. Box 9, 00014 Helsinki, Finland
    Division of Medical Problems of Cell Biology, Institute of Cell Biophysics, Institutional Street 3, Pushchino, Moscow region 142290, Russia)

  • Mirka Hintsanen

    (Department of Psychology, University of Helsinki, P.O. Box 9, 00014 Helsinki, Finland)

  • Niklas Ravaja

    (Center for Knowledge and Innovation Research, Helsinki School of Economics, P.O. Box 1210, 00101 Helsinki, Finland)

  • Markus Juonala

    (Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinanmyllynkatu 10, 20520 Turku, Finland)

  • Olli T. Raitakari

    (Department of Clinical Physiology, University of Turku, P.O. Box 52, 20521 Turku, Finland
    Department of Medicine, University of Turku and Turku University Hospital, P.O. Box 52, 20521 Turku, Finland)

  • Liisa Keltikangas-Järvinen

    (Department of Psychology, University of Helsinki, P.O. Box 9, 00014 Helsinki, Finland)

Abstract

This study aims to explore the interactive effect of vital exhaustion (VE) and endothelial dysfunction on preclinical atherosclerosis, assessed by carotid intima-media thickness (IMT). Furthermore, interaction between VE and carotid elasticity is examined. Participants were 1,596 young healthy adults from the Cardiovascular Risk in Young Finns study. Endothelial dysfunction was measured by brachial flow-mediated dilatation (FMD), and carotid elasticity by carotid artery compliance (CAC). Significant interactions between FMD and VE, and between CAC and VE, for IMT were found in participants with the very lowest FMD and CAC. Thus, VE may be harmful if the endothelium is not working properly.

Suggested Citation

  • Nadja Chumaeva & Mirka Hintsanen & Niklas Ravaja & Markus Juonala & Olli T. Raitakari & Liisa Keltikangas-Järvinen, 2009. "Chronic Stress and the Development of Early Atherosclerosis: Moderating Effect of Endothelial Dysfunction and Impaired Arterial Elasticity," IJERPH, MDPI, vol. 6(12), pages 1-16, November.
    • Handle: RePEc:gam:jijerp:v:6:y:2009:i:12:p:2934-2949:d:6333
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