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A History of Alcohol Dependence Increases the Incidence and Severity of Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

Author

Listed:
  • Judith A. Hudetz

    (Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA)

  • Kathleen M. Patterson

    (Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA
    Departments of Psychiatry, Behavioral Medicine, and Neurology Medical College of Wisconsin, Milwaukee, WI 53226, USA)

  • Alison J. Byrne

    (Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA)

  • Zafar Iqbal

    (Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA)

  • Sweeta D. Gandhi

    (Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA)

  • David C. Warltier

    (Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA)

  • Paul S. Pagel

    (Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA)

Abstract

Postoperative cognitive dysfunction (POCD) commonly occurs after cardiac surgery. We tested the hypothesis that a history of alcohol dependence is associated with an increased incidence and severity of POCD in male patients undergoing cardiac surgery using cardiopulmonary bypass. Recent verbal and nonverbal memory and executive functions were assessed before and one week after surgery in patients with or without a history of alcohol dependence. Cognitive function was significantly reduced after cardiac surgery in patients with versus without a history of alcohol dependence. The results suggest that a history of alcohol dependence increases the incidence and severity of POCD after cardiac surgery.

Suggested Citation

  • Judith A. Hudetz & Kathleen M. Patterson & Alison J. Byrne & Zafar Iqbal & Sweeta D. Gandhi & David C. Warltier & Paul S. Pagel, 2009. "A History of Alcohol Dependence Increases the Incidence and Severity of Postoperative Cognitive Dysfunction in Cardiac Surgical Patients," IJERPH, MDPI, vol. 6(11), pages 1-15, October.
    • Handle: RePEc:gam:jijerp:v:6:y:2009:i:11:p:2725-2739:d:6027
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