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Vernonia amygdalina : Anticancer Activity, Authentication, and Adulteration Detection

Author

Listed:
  • Lecia J. Gresham

    (The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies; College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
    Department of Biology, College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA)

  • Jetaime Ross

    (The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies; College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
    Department of Biology, College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA)

  • Ernest B. Izevbigie

    (The Laboratory of Cellular Signaling, Phytoceuticals, and Cancer Prevention and Therapies; College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
    Department of Biology, College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA
    NIH RCMI Center for Environmental Health, College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA)

Abstract

Evidence suggests that most chemotherapeutic agents are less effective as treatment in patients with estrogen receptor-negative (ER-) breast carcinomas compared to those with estrogen receptor-positive (ER+) breast carcinomas. Moreover, African American Women (AAW) is disproportionately diagnosed with ER- breast cancer compared to their white counterparts. Novel therapies effective against ER- breast carcinomas are urgently needed to ameliorate the health disparity. Previous reports show that low concentrations (microgram/ml) of water-soluble leaf extracts of a Nigerian edible plant, V. amygdalina (VA), potently retards the proliferative activities of ER+ human breast cancerous cells (MCF-7) in vitro in a concentration-dependent fashion. However, the anti-proliferative activities of VA in either ductal or ER- carcinoma cells have not been characterized. The exposure of BT-549 to increasing concentrations of VA (10, 100, and 1000 µg/mL) inhibited cell growth by approximately 14% (P

Suggested Citation

  • Lecia J. Gresham & Jetaime Ross & Ernest B. Izevbigie, 2008. "Vernonia amygdalina : Anticancer Activity, Authentication, and Adulteration Detection," IJERPH, MDPI, vol. 5(5), pages 1-7, December.
    • Handle: RePEc:gam:jijerp:v:5:y:2008:i:5:p:342-348:d:3757
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