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Effects of Benzo(a)pyrene on Intra-testicular Function in F-344 Rats

Author

Listed:
  • Anthony E. Archibong

    (Department of Obstetrics & Gynecology, Meharry Medical College, Nashville, TN 37208, USA)

  • Aramandla Ramesh

    (Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA)

  • Mohammad S. Niaz

    (Department of Obstetrics & Gynecology, Meharry Medical College, Nashville, TN 37208, USA)

  • Cynthia M. Brooks

    (Department of Obstetrics & Gynecology, Meharry Medical College, Nashville, TN 37208, USA)

  • Shannon I. Roberson

    (Department of Obstetrics & Gynecology, Meharry Medical College, Nashville, TN 37208, USA)

  • Donald D. Lunstra

    (U.S. Meat Animal Research Center, USDA, ARS, Clay Center, NE, 68933, USA)

Abstract

The objective of this study was to evaluate the reproductive risk associated with exposure of adult male Fisher-344 (F-344) rats to inhaled benzo(a)pyrene (BaP), a ubiquitous environmental toxicant present in cigarette smoke, automobile exhaust fumes and industrial emissions. Rats were assigned randomly to a treatment or control group. Treatment consisted of exposure of rats via nose-only inhalation to 75μg BaP/m 3 , 4 hours daily for 60 days, while control animals were unexposed (UNC). Blood samples were collected immediately on day 60 of exposures (time 0) and subsequently at 24, 48, and 72 hours, to assess the effect of exposures to BaP on plasma testosterone and luteinizing hormone (LH) concentrations. Mean testis weight, total weight of tubules and total tubular length per paired testes were reduced 33% (P

Suggested Citation

  • Anthony E. Archibong & Aramandla Ramesh & Mohammad S. Niaz & Cynthia M. Brooks & Shannon I. Roberson & Donald D. Lunstra, 2008. "Effects of Benzo(a)pyrene on Intra-testicular Function in F-344 Rats," IJERPH, MDPI, vol. 5(1), pages 1-9, March.
    • Handle: RePEc:gam:jijerp:v:5:y:2008:i:1:p:32-40:d:2292
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    Citations

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    Cited by:

    1. Kea M. Jones & Mohammad S. Niaz & Cynthia M. Brooks & Shannon I. Roberson & Maria P. Aguinaga & Edward R. Hills & Valerie Montgomery Rice & Phillip Bourne & Donald Bruce & Anthony E. Archibong, 2009. "Adverse Effects of a Clinically Relevant Dose of Hydroxyurea Used for the Treatment of Sickle Cell Disease on Male Fertility Endpoints," IJERPH, MDPI, vol. 6(3), pages 1-21, March.

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