IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v4y2007i2p153-157d2337.html
   My bibliography  Save this article

UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation

Author

Listed:
  • Diógenes Herreño Sáenz

    (Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, P.O. Box 365067, San Juan, Puerto Rico)

  • Qingsu Xia

    (National Center for Toxicological Research, Jefferson, AR 72079, USA)

  • Peter P. Fu

    (National Center for Toxicological Research, Jefferson, AR 72079, USA)

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants and potentially pose a health risk to humans. Although the biological and toxicological activities, including metabolism, mutagenicity and carcinogenicity of PAHs have been thoroughly studied, their phototoxicity and photo-induced biological activities have not been well examined. In this research, we studied the photoirradiation of isomeric methylbenzo[a]pyrene (MBaP) and methylbenzo[e]pyrene (MBeP) by UVA light in the presence of a lipid, methyl linoleate, and evaluated the potential of these compounds to induce lipid peroxidation. The compounds chosen for study included BaP, 3-MBaP, 4-MBaP, 6-MBaP, 7-MBaP, 10-MBaP, BeP, 4-MBeP, and 9-MBeP. The results indicate that upon photoirradiation by UVA at 7 and 21 J/cm 2 , these compounds induced lipid peroxidation. The levels of the induced lipid peroxidation were similar among BaP and the isomeric MBaPs, and among the BeP and MBePs, with the BaP group higher than the BeP group. There was also a co-relation between the UV A light dose and the level of lipid peroxidation induced. Lipid peroxide formation was inhibited by NaN 3 (singlet oxygen and free radical scavenger) and was enhanced by the presence of deuterium oxide (D 2 O) (extends singlet oxygen lifetime). These results suggest that photoirradiation of MBaPs and MBePs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation.

Suggested Citation

  • Diógenes Herreño Sáenz & Qingsu Xia & Peter P. Fu, 2007. "UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation," IJERPH, MDPI, vol. 4(2), pages 1-5, June.
    • Handle: RePEc:gam:jijerp:v:4:y:2007:i:2:p:153-157:d:2337
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/4/2/153/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/4/2/153/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Diógenes Herreno-Sáenz & Qingsu Xia & Li-Ting Chiu & Peter P. Fu, 2006. "UVA Photoirradiation of Halogenated-Polycyclic Aromatic Hydrocarbons Leading to Induction of Lipid Peroxidation," IJERPH, MDPI, vol. 3(2), pages 1-5, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Keywords

      n/a;

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:4:y:2007:i:2:p:153-157:d:2337. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.