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Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

Author

Listed:
  • Hongtao Yu

    (Department of Chemistry, Jackson State University, Jackson, MS 39217, USA)

  • Qingsu Xia

    (National Center for Toxicological Research, Jefferson, AR 72079, USA)

  • Jian Yan

    (Department of Chemistry, Jackson State University, Jackson, MS 39217, USA)

  • Diogenes Herreno-Saenz

    (Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico 00935)

  • Yuh-Shen Wu

    (Hung Kuang University, Sha-Lu, Taichung, Taiwan, ROC)

  • I-Wah Tang

    (National Center for Toxicological Research, Jefferson, AR 72079, USA)

  • Peter P. Fu

    (National Center for Toxicological Research, Jefferson, AR 72079, USA)

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the metabolic activation of PAHs leading to biological activities has been well studied, the photo-induced activation pathway has seldom reported. In this paper, we review the study of photoirradiation of PAHs with UVA irradiation results in (i) cytotoxicity and DNA damage (ii) DNA single strand cleavage; (iii) formation of 8-hydroxy-2’-deoxyguanosine adduct (8-OHdG), and (iv) formation of lipid peroxidation. Evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).

Suggested Citation

  • Hongtao Yu & Qingsu Xia & Jian Yan & Diogenes Herreno-Saenz & Yuh-Shen Wu & I-Wah Tang & Peter P. Fu, 2006. "Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage," IJERPH, MDPI, vol. 3(4), pages 1-7, December.
    • Handle: RePEc:gam:jijerp:v:3:y:2006:i:4:p:348-354:d:2412
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    Citations

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    Cited by:

    1. Yilin Yao & Jingyi Li & Hanhan Xue & Yutong Liu & Junpeng Qiao & Jingchun Tang & Rutao Liu & Qigui Niu, 2022. "Influences of Naphthalene Concentration on Starch Anaerobic Digestion: Focusing on Digestion Performance, Extracellular Polymeric Substances and Function Microbial Community," Sustainability, MDPI, vol. 14(24), pages 1-15, December.
    2. Hui-Chan Chen & Qingsu Xia & Shu-Hui Cherng & Shoujun Chen & Ching-Cheng Lai & Hongtao Yu & Peter P. Fu, 2007. "Synthesis and Photoirradiation of Isomeric Ethylchrysenes by UVA Light Leading to Lipid Peroxidation," IJERPH, MDPI, vol. 4(2), pages 1-8, June.

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