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Induced Mitogenic Activity in AML-12 Mouse Hepatocytes Exposed to Low-dose Ultra-Wideband Electromagnetic Radiation

Author

Listed:
  • W. C. Dorsey

    (Wildlife Biology Unit, Grambling State University, Grambling, LA. USA)

  • B. D. Ford

    (Department of Anatomy and Neurobiology, Morehouse School of Medicine, Atlanta, GA. USA)

  • L. Roane

    (Wildlife Biology Unit, Grambling State University, Grambling, LA. USA)

  • D. T. Haynie

    (Biomedical Engineering & Physics, Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA. USA)

  • P. B. Tchounwou

    (Molecular Toxicology Research Laboratory, NIH-Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS, USA)

Abstract

Ultra–wideband (UWB) technology has increased with the use of various civilian and military applications. In the present study, we hypothesized that low-dose UWB electromagnetic radiation (UWBR) could elicit a mitogenic effect in AML-12 mouse hepatocytes, in vitro . To test this hypothesis, we exposed AML-12 mouse hepatocytes, to UWBR in a specially constructed gigahertz transverse electromagnetic mode (GTEM) cell. Cells were exposed to UWBR for 2 h at a temperature of 23°C, a pulse width of 10 ns, a repetition rate of 1 kHz, and field strength of 5-20 kV/m. UWB pulses were triggered by an external pulse generator for UWBR exposure but were not triggered for the sham exposure. We performed an MTT Assay to assess cell viability for UWBR-treated and sham-exposed hepatocytes. Data from viability studies indicated a time-related increase in hepatocytes at time intervals from 8-24 h post exposure. UWBR exerted a statistically significant (p

Suggested Citation

  • W. C. Dorsey & B. D. Ford & L. Roane & D. T. Haynie & P. B. Tchounwou, 2005. "Induced Mitogenic Activity in AML-12 Mouse Hepatocytes Exposed to Low-dose Ultra-Wideband Electromagnetic Radiation," IJERPH, MDPI, vol. 2(1), pages 1-7, April.
    • Handle: RePEc:gam:jijerp:v:2:y:2005:i:1:p:24-30:d:2708
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    References listed on IDEAS

    as
    1. Waneene C. Dorsey & Paul B. Tchounwou & Dwayne Sutton, 2004. "Mitogenic and Cytotoxic Effects of Pentachlorophenol to AML 12 Mouse Hepatocytes," IJERPH, MDPI, vol. 1(2), pages 1-6, September.
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    1. Waneene C. Dorsey & Paul B. Tchounwou & Byron D. Ford, 2006. "Neuregulin 1-Βeta Cytoprotective Role in AML 12 Mouse Hepatocytes Exposed to Pentachlorophenol," IJERPH, MDPI, vol. 3(1), pages 1-12, March.

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