IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v22y2025i3p336-d1598835.html
   My bibliography  Save this article

Influence of CYP2C8 Polymorphism on the Exposure to Chloroquine in Patients with Malaria by Plasmodium vivax —A Preliminary Study

Author

Listed:
  • Luann Wendel Pereira de Sena

    (College of Collective Health, Federal University of the South and Southeast of Para, Cidade Universitaria, Avenida dos Ipês s/n, Maraba 68500000, Para, Brazil)

  • Hellen Thais Fuzii

    (Tropical Medicine Center, Para Federal University, Generalissimo Deodoro Street 92, Belem 66074740, Para, Brazil)

  • Fabiola Elizabeth Villanova

    (Tropical Medicine Center, Para Federal University, Generalissimo Deodoro Street 92, Belem 66074740, Para, Brazil)

  • Amanda Gabryelle Nunes Cardoso Mello

    (Pharmacy Faculty, Para Federal University, Campus Universitario do Guama, Augusto Correa Street 01, Belem 66074740, Para, Brazil)

  • Maria Pantoja Moreira de Sena

    (Postgraduate Program in Tropical Diseases, Para Federal University, Generalissimo Deodoro Street 92, Belem 66074740, Para, Brazil)

  • Michelle Valéria Dias Ferreira

    (Pharmacy Faculty, Para Federal University, Campus Universitario do Guama, Augusto Correa Street 01, Belem 66074740, Para, Brazil)

  • José Luiz Fernandes Vieira

    (Pharmacy Faculty, Para Federal University, Campus Universitario do Guama, Augusto Correa Street 01, Belem 66074740, Para, Brazil)

Abstract

Aim: To assess the impact of the CYP2C82 polymorphism on chloroquine and desethylchloroquine concentrations in patients with malaria caused by P. vivax . Methods: A prospective study was conducted on patients with malaria in an endemic area of the Amazon basin. Liquid chromatography was employed to measure the levels of chloroquine and desethylchloroquine, while molecular methods estimated the frequency of the CYP2C82 variant. Results: This study revealed that plasma levels of chloroquine were higher in patients with the CYP2C82 polymorphism compared to those without this variant. The difference in plasma levels ranged from 5% to 26.5%. Conversely, patients with the CYP2C82 polymorphism exhibited lower levels of desethylchloroquine. Conclusion: The findings of this study confirm the impairment of chloroquine metabolism by the CYP2C82 variant. However, it is noteworthy that in the dose regimen used for malaria treatment, these changes did not lead to toxic concentrations of the drug.

Suggested Citation

  • Luann Wendel Pereira de Sena & Hellen Thais Fuzii & Fabiola Elizabeth Villanova & Amanda Gabryelle Nunes Cardoso Mello & Maria Pantoja Moreira de Sena & Michelle Valéria Dias Ferreira & José Luiz Fern, 2025. "Influence of CYP2C8 Polymorphism on the Exposure to Chloroquine in Patients with Malaria by Plasmodium vivax —A Preliminary Study," IJERPH, MDPI, vol. 22(3), pages 1-5, February.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:3:p:336-:d:1598835
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/22/3/336/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/22/3/336/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:22:y:2025:i:3:p:336-:d:1598835. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.