IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v21y2024i8p1090-d1458608.html
   My bibliography  Save this article

Association between COVID-19 Vaccines and Menstrual Disorders: Retrospective Cohort Study of Women Aged 12–55 Years Old in Catalonia, Spain

Author

Listed:
  • Laura Esteban-Cledera

    (Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain
    Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain)

  • Carlo Alberto Bissacco

    (Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain)

  • Meritxell Pallejá-Millán

    (Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain)

  • Marcela Villalobos

    (Estudis de Ciències de la Salut, Universitat Oberta de Catalunya, 08012 Barcelona, Spain)

  • Felipe Villalobos

    (Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain)

Abstract

During the rapid development of COVID-19 vaccines, concerns emerged about potential adverse effects on menstrual health. This study examines the association between COVID-19 vaccination—considering the number of doses and vaccine type—and menstrual disorders, specifically heavy menstrual bleeding (HMB) and amenorrhea (AM). Utilizing electronic health records from the Sistema d’Informació per al Desenvolupament de la Investigació en Atenció Primària (SIDIAP) database in Catalonia, Spain, the retrospective cohort included 1,172,621 vaccinated women aged 12–55 with no prior menstrual disorders observed from 27 December 2020 to 30 June 2023. The incidence rate of HMB and AM increased with the second and third doses of the vaccine. Notably, the AstraZeneca ® and Janssen ® vaccines were associated with higher odds of HMB (OR: 1.765, CI: 1.527–2.033; OR: 2.155, CI: 1.873–2.476, respectively) and AM (OR: 1.623, CI: 1.416–1.854; OR: 1.989, CI: 1.740–2.269, respectively) from the first to the second dose compared to Pfizer/BioNTech ® . Conversely, the Moderna ® vaccine appeared to offer a protective effect against HMB (OR: 0.852, CI: 0.771–0.939) and AM (OR: 0.861, CI: 0.790–0.937) between the second and third doses. These results were adjusted for potential confounders, such as age, previous COVID-19 infection, and other relevant covariates.

Suggested Citation

  • Laura Esteban-Cledera & Carlo Alberto Bissacco & Meritxell Pallejá-Millán & Marcela Villalobos & Felipe Villalobos, 2024. "Association between COVID-19 Vaccines and Menstrual Disorders: Retrospective Cohort Study of Women Aged 12–55 Years Old in Catalonia, Spain," IJERPH, MDPI, vol. 21(8), pages 1-16, August.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:8:p:1090-:d:1458608
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/21/8/1090/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/21/8/1090/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:21:y:2024:i:8:p:1090-:d:1458608. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.