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Potential Role of Glyphosate, Glyphosate-Based Herbicides, and AMPA in Breast Cancer Development: A Review of Human and Human Cell-Based Studies

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  • Hannah M. Schluter

    (Department of Pathology and Laboratory Medicine, University of California, 839 Health Sciences Road, 218 Sprague Hall, Irvine, CA 92697, USA
    These authors contributed equally to this work.)

  • Hajar Bariami

    (Department of Pathology and Laboratory Medicine, University of California, 839 Health Sciences Road, 218 Sprague Hall, Irvine, CA 92697, USA
    These authors contributed equally to this work.)

  • Hannah Lui Park

    (Department of Pathology and Laboratory Medicine, University of California, 839 Health Sciences Road, 218 Sprague Hall, Irvine, CA 92697, USA)

Abstract

The potential connection between exposure to glyphosate and glyphosate-based herbicides (GBHs) and breast cancer risk is a topic of research that is rapidly gaining the public’s attention due to the conflicting reports surrounding glyphosate’s potential carcinogenicity. In this review, we synthesize the current published biomedical literature works that have explored associations of glyphosate, its metabolite, aminomethylphosphonic acid (AMPA), and GBHs with breast cancer risk in humans and human cell-based models. Using PubMed as our search engine, we identified a total of 14 articles that were included in this review. In the four human studies, urinary glyphosate and/or AMPA were associated with breast cancer risk, endocrine disruption, oxidative stress biomarkers, and changes in DNA methylation patterns. Among most of the 10 human cell-based studies, glyphosate exhibited endocrine disruption, induced altered gene expression, increased DNA damage, and altered cell viability, while GBHs were more cytotoxic than glyphosate alone. In summary, numerous studies have shown glyphosate, AMPA, and GBHs to have potential carcinogenic, cytotoxic, or endocrine-disruptive properties. However, more human studies need to be conducted in order for more definitive and supported conclusions to be made on their potential effects on breast cancer risk.

Suggested Citation

  • Hannah M. Schluter & Hajar Bariami & Hannah Lui Park, 2024. "Potential Role of Glyphosate, Glyphosate-Based Herbicides, and AMPA in Breast Cancer Development: A Review of Human and Human Cell-Based Studies," IJERPH, MDPI, vol. 21(8), pages 1-20, August.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:8:p:1087-:d:1458274
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    References listed on IDEAS

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    1. Lucia Coppola & Sabrina Tait & Enrica Fabbrizi & Monia Perugini & Cinzia La Rocca, 2022. "Comparison of the Toxicological Effects of Pesticides in Non-Tumorigenic MCF-12A and Tumorigenic MCF-7 Human Breast Cells," IJERPH, MDPI, vol. 19(8), pages 1-18, April.
    2. Liliana Garcia-Martinez & Yusheng Zhang & Yuichiro Nakata & Ho Lam Chan & Lluis Morey, 2021. "Epigenetic mechanisms in breast cancer therapy and resistance," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Nicolas Defarge & Eszter Takács & Verónica Laura Lozano & Robin Mesnage & Joël Spiroux de Vendômois & Gilles-Eric Séralini & András Székács, 2016. "Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels," IJERPH, MDPI, vol. 13(3), pages 1-17, February.
    4. Chao Zhang & Tiziana Schilirò & Marta Gea & Silvia Bianchi & Angelo Spinello & Alessandra Magistrato & Gianfranco Gilardi & Giovanna Di Nardo, 2020. "Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor," IJERPH, MDPI, vol. 17(16), pages 1-18, August.
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