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Inflammatory Status in Trained and Untrained Mice at Different Pollution Levels

Author

Listed:
  • Roberta Foster

    (Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil)

  • Mariana Matera Veras

    (Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil)

  • Andre Luis Lacerda Bachi

    (Post-Graduation Program in Health Science, University of Santo Amaro, São Paulo 04743-030, Brazil)

  • Jonatas Bussador do Amaral

    (Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil)

  • Victor Yuji Yariwake

    (Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil)

  • Dunia Waked

    (Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil)

  • Ana Clara Bastos Rodrigues

    (Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil)

  • Marilia Farrajota

    (Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil)

  • Robério Pereira Pires

    (Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil)

  • Karina Pantaleão

    (Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil)

  • Juliana de Melo Batista dos Santos

    (Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil)

  • Francys Helen Damian

    (Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil)

  • Paulo Hilário Saldiva

    (Experimental Atmospheric Pollution Laboratory, School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil)

  • Mauro Walter Vaisberg

    (Department of Otorhinolaryngology and Head and Neck Surgery, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo 04021-001, Brazil)

Abstract

Atmospheric pollution can be defined as a set of changes that occur in the composition of the air, making it unsuitable and/or harmful and thereby generating adverse effects on human health. The regular practice of physical exercise (PE) is associated with the preservation and/or improvement of health; however, it can be influenced by neuroimmunoendocrine mechanisms and external factors such as air pollution, highlighting the need for studies involving the practice of PE in polluted environments. Herein, 24 male C57BL/6 mice were evaluated, distributed into four groups (exposed to a high concentration of pollutants/sedentary, exposed to a high concentration of pollutants/exercised, exposed to ambient air/sedentary, and exposed to ambient air/exercised). The exposure to pollutants occurred in the environmental particle concentrator (CPA) and the physical training was performed on a treadmill specially designed for use within the CPA. Pro- and anti-inflammatory markers in blood and bronchoalveolar lavage (BALF), BALF cellularity, and lung tissue were evaluated. Although the active group exposed to a high concentration of pollution showed a greater inflammatory response, both the correlation analysis and the ratio between pro- and anti-inflammatory cytokines demonstrated that the exercised group presented greater anti-inflammatory activity, suggesting a protective/adaptative effect of exercise when carried out in a polluted environment.

Suggested Citation

  • Roberta Foster & Mariana Matera Veras & Andre Luis Lacerda Bachi & Jonatas Bussador do Amaral & Victor Yuji Yariwake & Dunia Waked & Ana Clara Bastos Rodrigues & Marilia Farrajota & Robério Pereira Pi, 2024. "Inflammatory Status in Trained and Untrained Mice at Different Pollution Levels," IJERPH, MDPI, vol. 21(7), pages 1-14, June.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:7:p:821-:d:1420653
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    References listed on IDEAS

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    1. David Rojas-Rueda & Emily Morales-Zamora & Wael Abdullah Alsufyani & Christopher H. Herbst & Salem M. AlBalawi & Reem Alsukait & Mashael Alomran, 2021. "Environmental Risk Factors and Health: An Umbrella Review of Meta-Analyses," IJERPH, MDPI, vol. 18(2), pages 1-38, January.
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