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An Assessment of the Ocular Toxicity of Two Major Sources of Environmental Exposure

Author

Listed:
  • Steven H. Rauchman

    (The Fresno Institute of Neuroscience, Fresno, CA 93730, USA)

  • Lora J. Kasselman

    (Research Institute, Hackensack Meridian Health, Edison, NJ 08502, USA)

  • Ankita Srivastava

    (Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA)

  • Joshua De Leon

    (Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA)

  • Allison B. Reiss

    (Department of Medicine and Biomedical Research Institute, NYU Grossman Long Island School of Medicine, Mineola, NY 11501, USA)

Abstract

The effect of airborne exposure on the eye surface is an area in need of exploration, particularly in light of the increasing number of incidents occurring in both civilian and military settings. In this study, in silico methods based on a platform comprising a portfolio of software applications and a technology ecosystem are used to test potential surface ocular toxicity in data presented from Iraqi burn pits and the East Palestine, Ohio, train derailment. The purpose of this analysis is to gain a better understanding of the long-term impact of such an exposure to the ocular surface and the manifestation of surface irritation, including dry eye disease. In silico methods were used to determine ocular irritation to chemical compounds. A list of such chemicals was introduced from a number of publicly available sources for burn pits and train derailment. The results demonstrated high ocular irritation scores for some chemicals present in these exposure events. Such an analysis is designed to provide guidance related to the needed ophthalmologic care and follow-up in individuals who have been in proximity to burn pits or the train derailment and those who will experience future toxic exposure.

Suggested Citation

  • Steven H. Rauchman & Lora J. Kasselman & Ankita Srivastava & Joshua De Leon & Allison B. Reiss, 2024. "An Assessment of the Ocular Toxicity of Two Major Sources of Environmental Exposure," IJERPH, MDPI, vol. 21(6), pages 1-12, June.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:6:p:780-:d:1415447
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    References listed on IDEAS

    as
    1. Wenjie Sun, 2023. "The Devastating Health Consequences of the Ohio Derailment: A Closer Look at the Effects of Vinyl Chloride Spill," IJERPH, MDPI, vol. 20(6), pages 1-2, March.
    2. Lisa M. Gargano & Kimberly Mantilla & Monique Fairclough & Shengchao Yu & Robert M. Brackbill, 2018. "Review of Non-Respiratory, Non-Cancer Physical Health Conditions from Exposure to the World Trade Center Disaster," IJERPH, MDPI, vol. 15(2), pages 1-17, February.
    Full references (including those not matched with items on IDEAS)

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