IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i6p5134-d1097227.html
   My bibliography  Save this article

Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study

Author

Listed:
  • Daniel Prieto-Botella

    (Department of Surgery and Pathology, Miguel Hernandez University, 03550 Alicante, Spain
    These authors have contributed equally to this work.)

  • Dries S. Martens

    (Centre for Environmental Sciences, Hasselt University, Agoralaan Gebouw D, BE-3590 Hasselt, Belgium)

  • Desiree Valera-Gran

    (Department of Surgery and Pathology, Miguel Hernandez University, 03550 Alicante, Spain
    Grupo de Investigación en Terapia Ocupacional (InTeO), Miguel Hernández University, 03550 Alicante, Spain
    Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), 03010 Alicante, Spain
    These authors have contributed equally to this work.)

  • Mikel Subiza-Pérez

    (Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, 20014 San Sebastian, Spain
    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
    Department of Clinical and Health Psychology and Research Methods, University of the Basque Country (UPV/EHU), 20018 Donostia-San Sebastián, Spain
    Bradford Institute for Health Research, Temple Bank House, Bradford Royal Infirmary, Duckworth Lane, Bradford BD9 6RJ, UK)

  • Adonina Tardón

    (Unidad de Epidemiología Molecular del Cáncer, Departamento de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Julián Clavería Street s/n, 33006 Oviedo, Spain
    Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001 Oviedo, Spain)

  • Manuel Lozano

    (Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, 46020 Valencia, Spain
    Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de València, 46100 Valencia, Spain)

  • Maribel Casas

    (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
    ISGlobal, Institute for Global Health, 08003 Barcelona, Spain
    Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain)

  • Mariona Bustamante

    (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
    ISGlobal, Institute for Global Health, 08003 Barcelona, Spain
    Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain)

  • Alba Jimeno-Romero

    (Department of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain)

  • Ana Fernández-Somoano

    (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
    Unidad de Epidemiología Molecular del Cáncer, Departamento de Medicina, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Julián Clavería Street s/n, 33006 Oviedo, Spain
    Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001 Oviedo, Spain)

  • Sabrina Llop

    (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
    Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, 46020 Valencia, Spain)

  • Martine Vrijheid

    (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
    ISGlobal, Institute for Global Health, 08003 Barcelona, Spain
    Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain)

  • Tim S. Nawrot

    (Centre for Environmental Sciences, Hasselt University, Agoralaan Gebouw D, BE-3590 Hasselt, Belgium
    Department of Public Health & Primary Care, University of Leuven (KU Leuven), BE-3000 Leuven, Belgium)

  • Eva-María Navarrete-Muñoz

    (Department of Surgery and Pathology, Miguel Hernandez University, 03550 Alicante, Spain
    Grupo de Investigación en Terapia Ocupacional (InTeO), Miguel Hernández University, 03550 Alicante, Spain
    Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), 03010 Alicante, Spain)

Abstract

Sedentary behaviour (SB) may be related to telomere length (TL) attrition due to a possible pro-inflammatory effect. This study examined the association between parent-reported sedentary behaviour (SB) and leukocyte TL at the age of 4 and telomere tracking from 4 to 8 years. In the Spanish birth cohort Infancia y Medio Ambiente (INMA) project, we analysed data from children who attended follow-up visits at age 4 (n = 669) and 8 (n = 530). Multiple robust regression models were used to explore the associations between mean daily hours of SB (screen time, other sedentary activities, and total SB) at 4 years categorised into tertiles and TL at 4 years and difference in TL rank between age 4 and 8, respectively. At the age of 4, the results showed that children with the highest screen time (1.6–5.0 h/day) had a shorter TL of −3.9% (95% CI: −7.4, −0.4; p = 0.03) compared with children in the lowest tertile (0.0–1.0 h/day). Between 4 and 8 years, a higher screen time (highest tertile group vs. lowest tertile) was associated with a decrease in the LTL rank of −1.9% (95% CI: −3.8, −0.1; p = 0.03) from 4 to 8 years. Children exposed to a higher screen time at 4 years were more prone to have shorter TL at 4 and between 4 and 8 years of age. This study supports the potential negative effect of SB during childhood on cellular longevity.

Suggested Citation

  • Daniel Prieto-Botella & Dries S. Martens & Desiree Valera-Gran & Mikel Subiza-Pérez & Adonina Tardón & Manuel Lozano & Maribel Casas & Mariona Bustamante & Alba Jimeno-Romero & Ana Fernández-Somoano &, 2023. "Sedentary Behaviour and Telomere Length Shortening during Early Childhood: Evidence from the Multicentre Prospective INMA Cohort Study," IJERPH, MDPI, vol. 20(6), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:5134-:d:1097227
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/6/5134/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/6/5134/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Xue, H.-M. & Liu, Q.-Q. & Tian, G. & Quan, L.-M. & Zhao, Y. & Cheng, G., 2017. "Television watching & telomere length among adults in southwest China," American Journal of Public Health, American Public Health Association, vol. 107(9), pages 1425-1432.
    2. repec:aph:ajpbhl:10.2105/ajph.2017.303879_4 is not listed on IDEAS
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xianglong Xu & Dengyuan Liu & Yunshuang Rao & Huan Zeng & Fan Zhang & Lu Wang & Yaojie Xie & Manoj Sharma & Yong Zhao, 2018. "Prolonged Screen Viewing Times and Sociodemographic Factors among Pregnant Women: A Cross-Sectional Survey in China," IJERPH, MDPI, vol. 15(3), pages 1-16, February.
    2. Ran Bao & Si-Tong Chen & Yanlei Wang & Jun Xu & Lei Wang & Liye Zou & Yujun Cai, 2020. "Sedentary Behavior Research in the Chinese Population: A Systematic Scoping Review," IJERPH, MDPI, vol. 17(10), pages 1-26, May.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:6:p:5134-:d:1097227. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.