IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i5p3915-d1077016.html
   My bibliography  Save this article

A Single Bout of Remote Ischemic Preconditioning Suppresses Ischemia-Reperfusion Injury in Asian Obese Young Men

Author

Listed:
  • Min-Hyeok Jang

    (Department of Physical Education, General Graduate School, Kyung Hee University, Yongin-si 17104, Republic of Korea)

  • Dae-Hwan Kim

    (Department of Physical Education, General Graduate School, Kyung Hee University, Yongin-si 17104, Republic of Korea)

  • Jean-Hee Han

    (Department of Physical Education, General Graduate School, Kyung Hee University, Yongin-si 17104, Republic of Korea)

  • Jahyun Kim

    (Department of Kinesiology, California State University Bakersfield, Bakersfield, CA 93311, USA)

  • Jung-Hyun Kim

    (Department of Sports Medicine, Kyung Hee University, Yongin-si 17104, Republic of Korea)

Abstract

Remote ischemic preconditioning (RIPC) has been shown to minimize subsequent ischemia-reperfusion injury (IRI), whereas obesity has been suggested to attenuate the efficacy of RIPC in animal models. The primary objective of this study was to investigate the effect of a single bout of RIPC on the vascular and autonomic response after IRI in young obese men. A total of 16 healthy young men (8 obese and 8 normal weight) underwent two experimental trials: RIPC (three cycles of 5 min ischemia at 180 mmHg + 5 min reperfusion on the left thigh) and SHAM (the same RIPC cycles at resting diastolic pressure) following IRI (20 min ischemia at 180 mmHg + 20 min reperfusion on the right thigh). Heart rate variability (HRV), blood pressure (SBP/DBP), and cutaneous blood flow (CBF) were measured between baseline, post-RIPC/SHAM, and post-IRI. The results showed that RIPC significantly improved the LF/HF ratio ( p = 0.027), SBP ( p = 0.047), MAP ( p = 0.049), CBF ( p = 0.001), cutaneous vascular conductance ( p = 0.003), vascular resistance ( p = 0.001), and sympathetic reactivity (SBP: p = 0.039; MAP: p = 0.084) after IRI. However, obesity neither exaggerated the degree of IRI nor attenuated the conditioning effects on the measured outcomes. In conclusion, a single bout of RIPC is an effective means of suppressing subsequent IRI and obesity, at least in Asian young adult men, does not significantly attenuate the efficacy of RIPC.

Suggested Citation

  • Min-Hyeok Jang & Dae-Hwan Kim & Jean-Hee Han & Jahyun Kim & Jung-Hyun Kim, 2023. "A Single Bout of Remote Ischemic Preconditioning Suppresses Ischemia-Reperfusion Injury in Asian Obese Young Men," IJERPH, MDPI, vol. 20(5), pages 1-9, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:5:p:3915-:d:1077016
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/5/3915/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/5/3915/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:5:p:3915-:d:1077016. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.