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Healthcare Resource Consumption and Related Costs in Patients on Antiretroviral Therapies: Findings from Real-World Data in Italy

Author

Listed:
  • Valentina Perrone

    (CliCon S.r.l. Società Benefit—Health, Economics & Outcomes Research, 40137 Bologna, Italy)

  • Melania Dovizio

    (CliCon S.r.l. Società Benefit—Health, Economics & Outcomes Research, 40137 Bologna, Italy)

  • Diego Sangiorgi

    (CliCon S.r.l. Società Benefit—Health, Economics & Outcomes Research, 40137 Bologna, Italy)

  • Margherita Andretta

    (Azienda ULSS 8 Berica, 36100 Vicenza, Italy)

  • Fausto Bartolini

    (USL Umbria 2 Terni, 05100 Terni, Italy)

  • Arturo Cavaliere

    (ASL Viterbo, 01100 Viterbo, Italy)

  • Andrea Ciaccia

    (Servizio Farmaceutico Territoriale ASL Foggia, 71121 Foggia, Italy)

  • Alessandro Chinellato

    (Azienda ULSS 3 Serenissima, 30174 Mestre, Italy)

  • Alberto Costantini

    (ASL Pescara, 65100 Pescara, Italy)

  • Stefania Dell’Orco

    (ASL Roma 6, 00041 Albano Laziale, Italy)

  • Fulvio Ferrante

    (ASL Frosinone, 03100 Frosinone, Italy)

  • Simona Gentile

    (Direzione Generale per la Salute Regione Molise, 86100 Campobasso, Italy)

  • Antonella Lavalle

    (Direzione Generale per la Salute Regione Molise, 86100 Campobasso, Italy)

  • Rossella Moscogiuri

    (ASL Taranto, 74121 Taranto, Italy)

  • Elena Mosele

    (UOC Assistenza Farmaceutica Territoriale, Azienda ULSS 7 Pedemontana, 36061 Bassano del Grappa, Italy)

  • Cataldo Procacci

    (Dipartimento Farmaceutico ASL BAT, 76125 Trani, Italy)

  • Davide Re

    (ASL Teramo, 64100 Teramo, Italy)

  • Fiorenzo Santoleri

    (ASL Pescara, 65100 Pescara, Italy)

  • Alessandro Roccia

    (Gilead Sciences S.r.l., 20124 Milano, Italy)

  • Franco Maggiolo

    (ASST Papa Giovanni XXIII, 24127 Bergamo, Italy)

  • Luca Degli Esposti

    (CliCon S.r.l. Società Benefit—Health, Economics & Outcomes Research, 40137 Bologna, Italy)

Abstract

This real-world analysis conducted on administrative databases of a sample of Italian healthcare entities was aimed at describing the role of therapeutic pathways and drug utilization in terms of adherence, persistence, and therapy discontinuation in HIV-infected patients under antiretroviral therapies (ART) and Tenofovir Alafenamide (TAF)-based regimens on healthcare resource consumption and related direct healthcare costs. Between 2015 and 2019, adults (≥18 years) prescribed with TAF-based therapies were identified and characterized in the year prior to the first prescription (index-date) for TAF-based therapies and followed-up until the end of data availability. Overall, 2658 ART-treated patients were included, 1198 of which were under a TAF-based regimen. TAF-based therapies were associated with elevated percentages of adherence (83.3% patients with proportion of days covered, PDC > 95% and 90.6% with PDC > 85%) and persistence (78.5%). The discontinuation rate was low in TAF-treated patients, ranging from 3.3% in TAF-switchers to 5% in naïve. Persistent patients had lower overall mean annual healthcare expenditures (EUR 11,106 in persistent vs. EUR 12,380 in non-persistent, p = 0.005), and this trend was statistically significant also for costs related to HIV hospitalizations. These findings suggest that a better therapeutic management of HIV infection might result in positive clinical and economic outcomes.

Suggested Citation

  • Valentina Perrone & Melania Dovizio & Diego Sangiorgi & Margherita Andretta & Fausto Bartolini & Arturo Cavaliere & Andrea Ciaccia & Alessandro Chinellato & Alberto Costantini & Stefania Dell’Orco & F, 2023. "Healthcare Resource Consumption and Related Costs in Patients on Antiretroviral Therapies: Findings from Real-World Data in Italy," IJERPH, MDPI, vol. 20(5), pages 1-12, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:5:p:3789-:d:1075402
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    References listed on IDEAS

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    1. Elisabetta Garagiola & Emanuela Foglia & Lucrezia Ferrario & Giovanni Cenderello & Antonio Di Biagio & Barbara Menzaghi & Giuliano Rizzardini & Davide Croce, 2020. "HTA and HIV: The Case of Dual NRTI Backbones in the Italian Setting," IJERPH, MDPI, vol. 17(23), pages 1-17, December.
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