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Beyond Sentinel Lymph Node: Outcomes of Indocyanine Green-Guided Pelvic Lymphadenectomy in Endometrial and Cervical Cancer

Author

Listed:
  • Benito Chiofalo

    (Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS “Regina Elena” National Cancer Institute, 00144 Rome, Italy)

  • Antonio Simone Laganà

    (Unit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy)

  • Fabio Ghezzi

    (Department of Obstetrics and Gynecology, “Filippo Del Ponte” Women and Children Hospital, University of Insubria, 21100 Varese, Italy)

  • Camilla Certelli

    (Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS “Regina Elena” National Cancer Institute, 00144 Rome, Italy)

  • Jvan Casarin

    (Department of Obstetrics and Gynecology, “Filippo Del Ponte” Women and Children Hospital, University of Insubria, 21100 Varese, Italy)

  • Valentina Bruno

    (Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS “Regina Elena” National Cancer Institute, 00144 Rome, Italy)

  • Isabella Sperduti

    (Biostatistical Unit, IRCCS “Regina Elena” National Cancer Institute, 00144 Rome, Italy)

  • Vito Chiantera

    (Unit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy)

  • Panagiotis Peitsidis

    (Department of Obstetrics and Gynecology, Helena Venizelou Hospital, 115 21 Athens, Greece)

  • Enrico Vizza

    (Gynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS “Regina Elena” National Cancer Institute, 00144 Rome, Italy)

Abstract

Background: The aim of our study was to compare the number of lymph nodes removed during indocyanine green (ICG)-guided laparoscopic/robotic pelvic lymphadenectomy with standard systematic lymphadenectomy in endometrial cancer (EC) and cervical cancer (CC). Methods: This is a multicenter retrospective comparative study (Clinical Trial ID: NCT04246580; updated on 31 January 2023). Women affected by EC and CC who underwent laparoscopic/robotic systematic pelvic lymphadenectomy, with (cases) or without (controls) the use of ICG tracer injection within the uterine cervix, were included in the study. Results: The two groups were homogeneous for age ( p = 0.08), Body Mass Index, International Federation of Gynaecology and Obstetrics (FIGO) stages ( p = 0.41 for EC; p = 0.17 for CC), median estimated blood loss ( p = 0.76), median operative time ( p = 0.59), and perioperative complications ( p = 0.66). Nevertheless, the number of lymph nodes retrieved during surgery was significantly higher ( p = 0.005) in the ICG group ( n = 18) compared with controls ( n = 16). Conclusions: The accurate and precise dissection achieved with the use of the ICG-guided procedure was associated with a higher number of lymph nodes removed in the case of systematic pelvic lymphadenectomy for EC and CC.

Suggested Citation

  • Benito Chiofalo & Antonio Simone Laganà & Fabio Ghezzi & Camilla Certelli & Jvan Casarin & Valentina Bruno & Isabella Sperduti & Vito Chiantera & Panagiotis Peitsidis & Enrico Vizza, 2023. "Beyond Sentinel Lymph Node: Outcomes of Indocyanine Green-Guided Pelvic Lymphadenectomy in Endometrial and Cervical Cancer," IJERPH, MDPI, vol. 20(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3476-:d:1070312
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    References listed on IDEAS

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    1. Basilio Pecorino & Maria Gabriella D’Agate & Giuseppe Scibilia & Paolo Scollo & Andrea Giannini & Mariano Catello Di Donna & Vito Chiantera & Antonio Simone Laganà, 2022. "Evaluation of Surgical Outcomes of Abdominal Radical Hysterectomy and Total Laparoscopic Radical Hysterectomy for Cervical Cancer: A Retrospective Analysis of Data Collected before the LACC Trial," IJERPH, MDPI, vol. 19(20), pages 1-9, October.
    2. Graziella Moufawad & Antonio Simone Laganà & Nassir Habib & Vito Chiantera & Andrea Giannini & Federico Ferrari & Amerigo Vitagliano & Luigi Della Corte & Giuseppe Bifulco & Zaki Sleiman, 2023. "Learning Laparoscopic Radical Hysterectomy: Are We Facing an Emerging Situation?," IJERPH, MDPI, vol. 20(3), pages 1-10, January.
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    1. Graziella Moufawad & Antonio Simone Laganà & Nassir Habib & Vito Chiantera & Andrea Giannini & Federico Ferrari & Amerigo Vitagliano & Luigi Della Corte & Giuseppe Bifulco & Zaki Sleiman, 2023. "Learning Laparoscopic Radical Hysterectomy: Are We Facing an Emerging Situation?," IJERPH, MDPI, vol. 20(3), pages 1-10, January.

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