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Influence of Agaricus bisporus Mushroom on Pb Toxicokinetic in Pregnant Rats

Author

Listed:
  • Érika Leão Ajala Caetano

    (Toxicological Research Laboratory–Lapetox, University of Sorocaba, Sorocaba 18023-000, SP, Brazil)

  • Tatiana Pedron

    (Center for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, SP, Brazil
    CIQ-UP Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4099-002 Porto, Portugal)

  • Bruna Moreira Freire

    (Center for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, SP, Brazil)

  • Camila Neves Lange

    (Center for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, SP, Brazil)

  • Bruno Lemos Batista

    (Center for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, SP, Brazil)

  • Denise Grotto

    (Center for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, SP, Brazil)

Abstract

(Pb) is a toxic metal, responsible for several damages to human health. Agaricus bisporus (Ab) is a mushroom with promising antioxidant properties to be used as an alternative chelator in Pb intoxication. The aim was to understand the Pb toxicokinetic and the potential of Ab as a protective agent. A total of 20 female Wistar rats were distributed into 4 groups (n = 5/group): Control (receiving water); Group Ab 100 mg/kg (gavage); Group Pb 100 mg/L in water; and Group Ab + Pb—100 mg/kg + 100 mg/L (gavage and water). Pb administration occurred daily until the 19th day of pregnancy. On day 19 of gestation, the rats were euthanized, and the blood and tissues were collected for Pb measurement, using an inductively coupled plasma mass spectrometer. The results showed that the levels of Pb in the blood, placenta, and liver of the mothers, and in the brain of the fetuses increased significantly in the Pb group. On the other hand, the combined exposure to Pb + Ab showed a significant decrease in the metal concentration in relation to the Pb group, returning to normal levels. Kidney and bone lead levels also increased significantly in the Pb group. However, in the combined exposure group, levels did not return to the control amounts; there was protection, but the Pb concentration was still significantly higher than in the control. In the brain, no significant differences were observed. In conclusion, we suggest A. bisporus is a natural chelator, because the co-administration of the mushroom was able to interact with Pb ions, minimizing the Pb absorption and distribution. These effects are suggested since A. bisporus have antioxidants and beta glucan that interact with Pb, chelating it and, thus, reducing its toxic effects.

Suggested Citation

  • Érika Leão Ajala Caetano & Tatiana Pedron & Bruna Moreira Freire & Camila Neves Lange & Bruno Lemos Batista & Denise Grotto, 2023. "Influence of Agaricus bisporus Mushroom on Pb Toxicokinetic in Pregnant Rats," IJERPH, MDPI, vol. 20(4), pages 1-9, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3114-:d:1064225
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    References listed on IDEAS

    as
    1. Iwona Mirończuk-Chodakowska & Anna Maria Witkowska, 2020. "Evaluation of Polish Wild Mushrooms as Beta-Glucan Sources," IJERPH, MDPI, vol. 17(19), pages 1-18, October.
    2. Shuxia Chen & Xiaoqing Shen & Siqiong Cheng & Panpan Li & Junna Du & Yanxia Chang & Huanwen Meng, 2013. "Evaluation of Garlic Cultivars for Polyphenolic Content and Antioxidant Properties," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-12, November.
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