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Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression—A Pilot Randomized Controlled Trial

Author

Listed:
  • Teris Cheung

    (School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China)

  • Tim Man Ho Li

    (Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China)

  • Yuen Shan Ho

    (School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China)

  • Georg Kranz

    (Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China)

  • Kenneth N. K. Fong

    (Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China)

  • Sau Fong Leung

    (School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China)

  • Simon Ching Lam

    (School of Nursing, Tung Wah College, Hong Kong SAR, China)

  • Wing Fai Yeung

    (School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China)

  • Joyce Yuen Ting Lam

    (School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China)

  • Kwan Hin Fong

    (School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China)

  • Roland Beisteiner

    (Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria)

  • Yu-Tao Xiang

    (Unit of Psychiatry, Department of Public Health and Medicinal Administration, Institute of Translational Medicine, University of Macau, Macao SAR, China)

  • Calvin Pak Wing Cheng

    (Department of Psychiatry, University of Hong Kong, Hong Kong SAR, China)

Abstract

Transcranial pulse stimulation (TPS) is a recent development in non-invasive brain stimulations (NIBS) that has been proven to be effective in terms of significantly improving Alzheimer patients’ cognition, memory, and execution functions. Nonetheless, there is, currently, no trial evaluating the efficacy of TPS on adults with major depression disorder (MDD) nationwide. In this single-blinded, randomized controlled trial, a 2-week TPS treatment comprising six 30 min TPS sessions were administered to participants. Participants were randomized into either the TPS group or the Waitlist Control (WC) group, stratified by gender and age according to a 1:1 ratio. Our primary outcome was evaluated by the Hamilton depression rating scale-17 (HDRS-17). We recruited 30 participants that were aged between 18 and 54 years, predominantly female (73%), and ethnic Chinese from 1 August to 31 October 2021. Moreover, there was a significant group x time interaction (F(1, 28) = 18.8, p < 0.001). Further, when compared with the WC group, there was a significant reduction in the depressive symptom severity in the TPS group (mean difference = −6.60, p = 0.02, and Cohen’s d = −0.93). The results showed a significant intervention effect; in addition, the effect was large and sustainable at the 3-month follow-up. In this trial, it was found that TPS is effective in reducing depressive symptoms among adults with MDD.

Suggested Citation

  • Teris Cheung & Tim Man Ho Li & Yuen Shan Ho & Georg Kranz & Kenneth N. K. Fong & Sau Fong Leung & Simon Ching Lam & Wing Fai Yeung & Joyce Yuen Ting Lam & Kwan Hin Fong & Roland Beisteiner & Yu-Tao Xi, 2023. "Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression—A Pilot Randomized Controlled Trial," IJERPH, MDPI, vol. 20(3), pages 1-17, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:3:p:2333-:d:1049536
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    References listed on IDEAS

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    1. Kenneth F Schulz & Douglas G Altman & David Moher & for the CONSORT Group, 2010. "CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials," PLOS Medicine, Public Library of Science, vol. 7(3), pages 1-7, March.
    2. Ben Y. F. Fong & Martin C. S. Wong & Vincent T. S. Law & Man Fung Lo & Tommy K. C. Ng & Hilary H. L. Yee & Tiffany C. H. Leung & Percy W. T. Ho, 2020. "Relationships between Physical and Social Behavioural Changes and the Mental Status of Homebound Residents in Hong Kong during the COVID-19 Pandemic," IJERPH, MDPI, vol. 17(18), pages 1-18, September.
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