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Which Is the Most Appropriate Cut-Off of HbA1c for Prediabetes Screening in Caucasian Youths with Overweight or Obesity?

Author

Listed:
  • Procolo Di Bonito

    (Department of Internal Medicine, “S. Maria delle Grazie” Hospital, 80078 Pozzuoli, Italy)

  • Maria Rosaria Licenziati

    (Neuro-Endocrine Diseases and Obesity Unit, Department of Neurosciences, Santobono-Pausilipon Children’s Hospital, 80139 Napoli, Italy)

  • Domenico Corica

    (Department of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, Italy)

  • Malgorzata Wasniewska

    (Department of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, Italy)

  • Anna Di Sessa

    (Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Napoli, Italy)

  • Emanuele Miraglia del Giudice

    (Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Napoli, Italy)

  • Anita Morandi

    (Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy)

  • Claudio Maffeis

    (Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy)

  • Maria Felicia Faienza

    (Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70121 Bari, Italy)

  • Enza Mozzillo

    (Section of Pediatrics, Department of Translational Medical Science, Regional Center of Pediatric Diabetes, University of Naples “Federico II”, 80131 Napoli, Italy)

  • Valeria Calcaterra

    (Pediatric Department, “V. Buzzi” Children’s Hospital, 20154 Milano, Italy
    Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy)

  • Francesca Franco

    (Pediatric Department, Azienda Sanitaria Universitaria Friuli Centrale, Hospital of Udine, 33100 Udine, Italy)

  • Giulio Maltoni

    (Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy)

  • Giuliana Valerio

    (Department of Movement Sciences and Wellbeing, University of Napoli “Parthenope”, 80133 Napoli, Italy)

Abstract

This cross-sectional study aimed to assess the best cut-off of HbA1c for detection of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), beta-cell impairment and cardiometabolic risk (CMR) profile in overweight or obese (OW/OB) Caucasian youths. Two-hour oral glucose tolerance test was available in 1549 youths, one-hour glucose (G 60 ) in 1430 youths and disposition index (DI) in 972 youths. Insulin resistance (IR) was calculated as Homeostatic Model Assessment for IR and insulin sensitivity (IS) as 1/fasting insulin. High G 60 was defined by a value ≥ 133 mg/dL. The best cut-off of HbA1c for IFG or IGT was 5.5%. The frequency of individuals with HbA1c ≥ 5.5% was 32.5%, compared to 16.3% with HbA1c ≥ 5.7% (as proposed by the American Diabetes Association). HbA1c ≥ 5.5% showed higher sensitivity and lower specificity with respect to HbA1c ≥ 5.7% for all the abnormalities examined (IFG, IGT, high G 60 , IR, low IS, DI and CMR factors). In conclusion, this lower cut-off might represent a more appropriate screening marker of glucose dysmetabolism in youths with OW/OB. Prospective studies are needed to validate this cut-off for predicting prediabetes/diabetes in youths with OW/OB.

Suggested Citation

  • Procolo Di Bonito & Maria Rosaria Licenziati & Domenico Corica & Malgorzata Wasniewska & Anna Di Sessa & Emanuele Miraglia del Giudice & Anita Morandi & Claudio Maffeis & Maria Felicia Faienza & Enza , 2023. "Which Is the Most Appropriate Cut-Off of HbA1c for Prediabetes Screening in Caucasian Youths with Overweight or Obesity?," IJERPH, MDPI, vol. 20(2), pages 1-9, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:2:p:928-:d:1025049
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    References listed on IDEAS

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    1. Gabriela Cavagnolli & Ana Laura Pimentel & Priscila Aparecida Correa Freitas & Jorge Luiz Gross & Joíza Lins Camargo, 2017. "Effect of ethnicity on HbA1c levels in individuals without diabetes: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-14, February.
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