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Effect of Familial Longevity on Frailty and Sarcopenia: A Case–Control Study

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  • Angel Belenguer-Varea

    (Division of Geriatrics, Hospital Universitario de la Ribera, 46600 Valencia, Spain
    School of Doctorate, Universidad Católica de Valencia San Vicente Martir, 46001 Valencia, Spain)

  • Juan Antonio Avellana-Zaragoza

    (Division of Geriatrics, Hospital Universitario de la Ribera, 46600 Valencia, Spain
    School of Doctorate, Universidad Católica de Valencia San Vicente Martir, 46001 Valencia, Spain)

  • Marta Inglés

    (Freshage Research Group, Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain)

  • Cristina Cunha-Pérez

    (School of Doctorate, Universidad Católica de Valencia San Vicente Martir, 46001 Valencia, Spain)

  • David Cuesta-Peredo

    (Department of Quality Management, Hospital Universitario de la Ribera, 46600 Valencia, Spain)

  • Consuelo Borrás

    (Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain)

  • José Viña

    (Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES-ISCIII, INCLIVA, 46010 Valencia, Spain)

  • Francisco José Tarazona-Santabalbina

    (Division of Geriatrics, Hospital Universitario de la Ribera, 46600 Valencia, Spain
    School of Doctorate, Universidad Católica de Valencia San Vicente Martir, 46001 Valencia, Spain
    Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), 46010 Valencia, Spain)

Abstract

Familial longevity confers advantages in terms of health, functionality, and longevity. We sought to assess potential differences in frailty and sarcopenia in older adults according to a parental history of extraordinary longevity. A total of 176 community-dwelling subjects aged 65–80 years were recruited in this observational case–control study, pair-matched 1:1 for gender, age, and place of birth and residence: 88 centenarians’ offspring (case group) and 88 non-centenarians’ offspring (control group). The main variables were frailty and sarcopenia based on Fried’s phenotype and the European Working Group on Sarcopenia in Older People (EWGSOP) definitions, respectively. Sociodemographics, comorbidities, clinical and functional variables, the presence of geriatric syndromes, and laboratory parameters were also collected. Related sample tests were applied, and conditional logistic regression was performed. Cases had a higher percentage of robust patients (31.8% vs. 15.9%), lower percentages of frailty (9.1% vs. 21.6%) and pre-frailty (59.1% vs. 62.5%) ( p = 0.001), and lower levels of IL-6 ( p = 0.044) than controls. The robust adjusted OR for cases was 3.00 (95% CI = 1.06–8.47, p = 0.038). No significant differences in muscle mass were found. Familial longevity was also associated with less obesity, insomnia, pain, and polypharmacy and a higher education level and total and low-density lipoprotein cholesterol. The results suggest an inherited genetic component in the frailty phenotype, while the sarcopenia association with familial longevity remains challenging.

Suggested Citation

  • Angel Belenguer-Varea & Juan Antonio Avellana-Zaragoza & Marta Inglés & Cristina Cunha-Pérez & David Cuesta-Peredo & Consuelo Borrás & José Viña & Francisco José Tarazona-Santabalbina, 2023. "Effect of Familial Longevity on Frailty and Sarcopenia: A Case–Control Study," IJERPH, MDPI, vol. 20(2), pages 1-16, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:2:p:1534-:d:1035747
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    References listed on IDEAS

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    1. Chiara Airoldi & Daniela Ferrante & Dario Mirabelli & Danila Azzolina & Corrado Magnani, 2020. "Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma," IJERPH, MDPI, vol. 17(17), pages 1-9, August.
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