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Impact of Metformin on Periodontal and Peri-Implant Soft and Hard Tissue

Author

Listed:
  • Faisal E. Aljofi

    (Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

  • Aminah Alesawy

    (Fellowship in Periodontics Program, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

  • Bader Alzaben

    (Fellowship in Periodontics Program, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

  • Marwa Alshaikh

    (Fellowship in Periodontics Program, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

  • Norah Alotaibi

    (Fellowship in Periodontics Program, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

  • Hajer A. Aldulaijan

    (Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh P.O. Box 60169, Saudi Arabia)

  • Sami Alshehri

    (Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

  • Eman Aljoghaiman

    (Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

  • Yousif A. Al-Dulaijan

    (Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

  • Mishali AlSharief

    (Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia)

Abstract

Periodontal and peri-implant soft and hard tissue in diabetic patients have always been a topic of interest for researchers and clinicians alike. Among which, a subtopic that has attracted more attention is the beneficial effect of metformin (MF) on periodontal and peri-implant soft and hard tissue. This review aimed to assess the impact of MF on the periodontal and peri-implant soft- and hard-tissue healing among diabetic patients. Research was conducted using the keywords ‘metformin’, ‘diabetes’, ‘periodontitis’, ‘implant’, and ‘peri-implantitis’ via the Medline (PubMed) and Google Scholar databases. Selected articles were reviewed. A total of 21 articles, discussing the impact on periodontal health (six animal studies, seven clinical studies, and three systematic reviews) and five studies on peri-implant health (four animal studies and one clinical study) were included. All have reported a positive impact of MF on decreasing the inflammatory response, oxidative stress, and ultimate bone loss. Similarly, human studies reported a positive effect of MF on clinical and radiographic parameters compared with controls. Despite systematic reviews reporting heterogeneity among the included studies, MF has shown a positive impact on periodontal health. In animal, clinical studies, and systematic reviews, MF showed a protective impact on periodontal and peri-implant health.

Suggested Citation

  • Faisal E. Aljofi & Aminah Alesawy & Bader Alzaben & Marwa Alshaikh & Norah Alotaibi & Hajer A. Aldulaijan & Sami Alshehri & Eman Aljoghaiman & Yousif A. Al-Dulaijan & Mishali AlSharief, 2023. "Impact of Metformin on Periodontal and Peri-Implant Soft and Hard Tissue," IJERPH, MDPI, vol. 20(2), pages 1-12, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:2:p:1095-:d:1028750
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    References listed on IDEAS

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    1. Shun-ichi Harada & Gideon A. Rodan, 2003. "Control of osteoblast function and regulation of bone mass," Nature, Nature, vol. 423(6937), pages 349-355, May.
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