IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i2p1027-d1026869.html
   My bibliography  Save this article

Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study

Author

Listed:
  • Sejong Jin

    (Department of Neuroscience, Korea University College of Medicine, Seoul 02841, Republic of Korea
    These authors contributed equally to this work.)

  • Eun-Ji Choi

    (Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Yangsan 50612, Republic of Korea
    These authors contributed equally to this work.)

  • Yoon Ji Choi

    (Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea)

  • Won Kee Min

    (Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea)

  • Ju Yeon Park

    (Department of Anesthesiology and Pain Medicine, Daedong Hospital, Busan 47737, Republic of Korea)

  • Seung Zhoo Yoon

    (Department of Anesthesiology and Pain Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea)

Abstract

Patients with peripheral arterial disease (PAD) are at a higher risk of developing postoperative complications. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays an important role in atherosclerosis pathogenesis. In this study, the relationship between PAD and several single nucleotide polymorphisms (SNPs) of ALOX5AP (rs17216473, rs10507391, rs4769874, rs9551963, rs17222814, and rs7222842) was investigated in elderly patients undergoing general surgery. The medical records of 129 patients aged > 55 years who underwent elective general surgery between May 2018 and August 2019 were retrospectively reviewed. The A/A in rs17216473, A/A in rs10507391, G/G in rs4769874, and A/A in rs9551963 were calculated as 0 points and the rest as 1 point to define the genetic risk score. The prevalence of PAD tended to increase with higher genetic risk scores (patients had less ALOX5AP gene polymorphism of A/A in rs17216473, A/A in rs10507391, G/G in rs4769874, or A/A in rs9551963) ( p = 0.005). Multivariate logistic regression analysis revealed that the genetic risk score ( p = 0.009) and age ( p = 0.007) were positively correlated with the prevalence of PAD. Genetic polymorphisms of ALOX5AP and age were associated with the prevalence of PAD in this study.

Suggested Citation

  • Sejong Jin & Eun-Ji Choi & Yoon Ji Choi & Won Kee Min & Ju Yeon Park & Seung Zhoo Yoon, 2023. "Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study," IJERPH, MDPI, vol. 20(2), pages 1-9, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:2:p:1027-:d:1026869
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/2/1027/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/2/1027/
    Download Restriction: no
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:2:p:1027-:d:1026869. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.