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Antidiabetic Therapy during Pregnancy: The Prescription Pattern in Italy

Author

Listed:
  • Anna Locatelli

    (School of Medicine and Surgery, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy)

  • Sara Ornaghi

    (School of Medicine and Surgery, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy)

  • Alessandra Terzaghi

    (School of Medicine and Surgery, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy)

  • Valeria Belleudi

    (Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, 00147 Rome, Italy)

  • Filomena Fortinguerra

    (Italian Medicines Agency (AIFA), 00187 Rome, Italy)

  • Francesca Romana Poggi

    (Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, 00147 Rome, Italy)

  • Serena Perna

    (Italian Medicines Agency (AIFA), 00187 Rome, Italy)

  • Francesco Trotta

    (Italian Medicines Agency (AIFA), 00187 Rome, Italy)

  • MoM-Net Group

    (Membership of the Group is provided in the Appendix A.)

Abstract

Pregestational and gestational diabetes mellitus are relevant complications of pregnancy, and antidiabetic drugs are prescribed to obtain glycemic control and improve perinatal outcomes. The objective of this study was to describe the prescription pattern of antidiabetics before, during and after pregnancy in Italy and to evaluate its concordance with the Italian guideline on treatment of diabetes mellitus. A multi-database cross-sectional population study using a Common Data Model was performed. In a cohort of about 450,000 women, the prescribing profile of antidiabetics seemed to be in line with the Italian guideline, which currently does not recommend the use of oral antidiabetics and non-insulin injection, even if practice is still heterogeneous (up to 3.8% in the third trimester used oral antidiabetics). A substantial variability in the prescription pattern was observed among the Italian regions considered: the highest increase was registered in Tuscany (4.2%) while the lowest was in Lombardy (1.5%). Women with multiple births had a higher proportion of antidiabetic prescriptions than women with singleton births both in the preconception period and during pregnancy (1.3% vs. 0.7%; 3.4% vs. 2.6%) and used metformin more frequently. The consumption of antidiabetics in foreign women was higher than Italians (second trimester: 1.8% vs. 0.9%, third trimester: 3.6% vs. 1.8%).

Suggested Citation

  • Anna Locatelli & Sara Ornaghi & Alessandra Terzaghi & Valeria Belleudi & Filomena Fortinguerra & Francesca Romana Poggi & Serena Perna & Francesco Trotta & MoM-Net Group, 2023. "Antidiabetic Therapy during Pregnancy: The Prescription Pattern in Italy," IJERPH, MDPI, vol. 20(23), pages 1-13, December.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:23:p:7139-:d:1293844
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    References listed on IDEAS

    as
    1. Michelle Lende & Asha Rijhsinghani, 2020. "Gestational Diabetes: Overview with Emphasis on Medical Management," IJERPH, MDPI, vol. 17(24), pages 1-12, December.
    2. Paola D’Aloja & Roberto Da Cas & Valeria Belleudi & Filomena Fortinguerra & Francesca Romana Poggi & Serena Perna & Francesco Trotta & Serena Donati & MoM-Net Group, 2022. "Drug Prescriptions among Italian and Immigrant Pregnant Women Resident in Italy: A Cross-Sectional Population-Based Study," IJERPH, MDPI, vol. 19(7), pages 1-11, April.
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